Clinical Oncology:调强放疗同步化疗治肛门癌有效

2012-08-03 朱金 医学论坛网

  《临床肿瘤学》(Clinical Oncology)杂志近期发表的一项研究可能证明了调强放疗同步化疗用于治疗肛门癌有效且患者对其耐受性良好。   该研究纳入了78例在13个社区癌症中心接受调强放疗(IMRT)治疗的肛门癌患者。65例(83%)为T1~T2期,64%为N0期,9%为M1期;5例患者为HIV阳性。除1例患者外,所有患者均同步接受化疗。包括腹股沟淋巴结在内的骨盆的中位照射

  《临床肿瘤学》(Clinical Oncology)杂志近期发表的一项研究可能证明了调强放疗同步化疗用于治疗肛门癌有效且患者对其耐受性良好。

  该研究纳入了78例在13个社区癌症中心接受调强放疗(IMRT)治疗的肛门癌患者。65例(83%)为T1~T2期,64%为N0期,9%为M1期;5例患者为HIV阳性。除1例患者外,所有患者均同步接受化疗。包括腹股沟淋巴结在内的骨盆的中位照射剂量是45 Gy。原发部位和受累淋巴结的中位照射剂量被提高至55.8 Gy。

  结果显示,研究对整个队列中位随访16个月(范围:0~72 个月)。≥3级急性毒性反应包括胃肠道的27.7%和皮肤的29.0%。12.9%的患者发生了4级急性血液学毒性。64例(88.9%)患者完全缓解。2年无结肠造口术生存、总生存、无局部复发和无远处复发的概率分别是 81.2%、86.9%、83.6%和81.8%。

  相关链接:Defoe SG, Beriwal S, Jones H, Rakfal S, Heron DE, Kabolizadeh P, Smith RP, Lalonde R.Concurrent Chemotherapy and Intensity-modulated Radiation Therapy for Anal Carcinoma - Clinical Outcomes in a Large National Cancer Institute-designated Integrated Cancer Centre Network.Clin Oncol,2012 Aug;24(6):424-31



    

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    2013-04-03 minlingfeng
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    2013-04-19 hxj0127
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    2012-08-05 zll0628

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