J Cosmet Dermatol:A型肉毒杆菌毒素可有效改善唇腭裂术后的瘢痕肥大

2022-08-07 MedSci原创 MedSci原创

唇裂和/或腭裂(CL/P)是先天性面部发育畸形,是由胚胎面部融合过程中的错误造成,严重影响患者的美观和社会行为。手术是解决唇腭裂面部畸形的重要治疗方法,但术后疤痕仍会影响患者的心理健康。

唇裂和/或腭裂(CL/P)是先天性面部发育畸形,是由胚胎面部融合过程中的错误造成,严重影响患者的美观和社会行为。手术是解决唇腭裂面部畸形的重要治疗方法,但术后疤痕仍会影响患者的心理健康。如何减少并淡化这些疤痕是整形外科医生和患者共同面临的问题。近日,发表于J Cosmet Dermatol的一项研究旨在系统地评估A型肉毒杆菌毒素(BTXA)在预防和治疗术后CL/P疤痕及改善疤痕质量方面的疗效。

研究人员系统搜索了PubMed、EMBASE、Cochrane图书馆和Web of Science中收录的相关试验,进行系统回顾。所有相关试验均在2021年6月30日之前进行。将数据输入Revman 5.3软件,并通过使用随机效应模型或固定效应模型进行荟萃分析。

 

结果,该项荟萃分析共纳入了4项随机对照试验,包括161例患者。定量分析结果显示,BTXA在预防和治疗术后CL/P疤痕方面显示出明显差异,包括疤痕宽度(MD:-0.20;[95%CI,-0.30,-0.10],P<0.0001)和视觉模拟量表(VAS)(MD:1. 30; [95% CI, 1.06, 1.55], p < 0.0001),但是两组之间在温哥华疤痕量表(VSS)(MD: -0.75; [95% CI, -1.68, 0.19], p = 0.12)上没有明显的差异。

综上所述,该研究结果表明,在预防和治疗术后CL/P疤痕肥大方面,BTXA注射液可以显示出更好的效果。排除部分研究后,由于注射时间-术前/术中或成人CL/P疤痕,结果之间没有统计学上的显著差异。为了提供更确切的数据,应该对用BTXA治疗CL/P疤痕的更多高质量的RCT进行更彻底地比较。

原始出处:

Qiang Ji et al., Botulinum toxin type A for preventing and treating cleft lip scarring-A systematic review and meta-analysis. J Cosmet Dermatol. 2022 Jun;21(6):2331-2337. doi: 10.1111/jocd.14941. 

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    2023-05-27 一闲
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    2022-11-21 tcm99hq
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    2022-08-07 医鸣惊人

    认真学习了

    0

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A型肉毒杆菌毒素(BTX-A)是治疗面肌痉挛(HFS)的一种选择,其短暂作用约为3-4个月。 注射后立即进行积极的肌肉锻炼可能会增强其功效。 一项针对面部运动异常的面部锻炼和BTX-A联合进行的小型随

Aesthet Surg J:A型肉毒杆菌毒素可显著减小下眼睑疤痕

下眼睑整形术是一种常见的美容手术,主要依赖于术后疤痕极小,但亚洲患者比白种人更容易出现瘢痕肥厚和/或扩大。A型肉毒杆菌毒素(BTX)注射被广泛用于缓解面部动态皱纹,也可以通过减少疤痕张力来改善疤痕大小

J Cosmet Dermatol:A型肉毒杆菌毒素似乎可有效预防和治疗唇腭裂术后的瘢痕

唇裂和/或腭裂(CL/P)是先天性面部裂缝畸形,是由胚胎面部融合过程中的错误造成的异常发育,严重影响患者的美观和社会行为。整形手术是一种重要的治疗方法,但术后疤痕仍会给患者带来心理阴影。