Science China子刊:霍勇/葛均波团队揭示我国疫情不同时期STEMI患者院内死亡的双峰现象

2022-05-10 张楠 心血管健康联盟信息平台 发表于威斯康星

由于新冠疫情反复,许多国家和地区都在经历周期性的封锁和解封。早期研究显示,新冠疫情的爆发对STEMI患者带来了多方面的影响,包括住院率的下降、血运重建方式的改变和救治时间的延长等,但尚缺乏封锁和解封对

由于新冠疫情反复,许多国家和地区都在经历周期性的封锁和解封。早期研究显示,新冠疫情的爆发对STEMI患者带来了多方面的影响,包括住院率的下降、血运重建方式的改变和救治时间的延长等,但尚缺乏封锁和解封对STEMI死亡影响的相关研究。

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近日,北京大学第一医院霍勇教授课题组和复旦大学附属中山医院葛均波院士课题组合作在《Science China Life Sciences》发表了题为Twin peaks of in-hospital mortality among patients with STEMI across five phases of COVID-19 outbreak in China: a nation-wide study 的研究论文,揭示了疫情不同时期下全国STEMI患者院内死亡风险的双峰趋势及可能的影响因素。

研究者通过分析2019年1月1日至2020年5月31日中国4487家胸痛中心就诊的283661名STEMI患者数据后发现,与封锁前相比,封锁早期和解封早期,STEMI院内死亡风险分别显著升高25%(OR 1.25,95%CI 1.16-1.34)和35%(OR 1.35,95%CI 1.21-1.50),并在解封晚期恢复到疫情前水平(OR 1.04,95%CI 0.95-1.14)。此外,按照血运重建方式及救治时间分层后,在疫情的五个阶段,STEMI患者呈现相同的死亡率梯度:无论是封锁期间还是解封后,接受PPCI治疗的患者死亡率均处于最低水平。

研究者认为,造成双峰现象的原因是复杂的,医院层面、社会层面及患者个人可能共同造成双峰现象的出现。除缩短救治时间外,加强封锁期间高危人群慢病管理及远程医疗,关注高危人群心理健康等都可能有效缓解STEMI死亡风险的上升。

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图1. 疫情不同时期及2019年同期的STEMI患者院内死亡率趋势

 

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图2.按照血运重建方式及救治时间分层的STEMI患者院内死亡率三维图

第一作者:北京大学第一医院 李建平教授

共同通讯作者:北京大学第一医院 霍勇教授,复旦大学附属中山医院 葛均波院士

文献来源:Li, J., Zhang, N., Zhou, Z. et al. Twin peaks of in-hospital mortality among patients with STEMI across five phases of COVID-19 outbreak in China: a nation-wide study. Sci. China Life Sci. (2022). https://doi.org/10.1007/s11427-021-2046-4

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  1. 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    2022-06-13 drwjr
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  4. 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createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=赛华佗, createdTime=Wed May 11 08:04:29 CST 2022, time=2022-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218636, encodeId=dbeb12186364f, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8ba6319857, createdName=1064510_1039, createdTime=Wed May 11 07:03:26 CST 2022, time=2022-05-11, status=1, ipAttribution=)]
    2022-05-30 屋顶瞄爱赏月

    签到学习

    0

  5. 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createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=赛华佗, createdTime=Wed May 11 08:04:29 CST 2022, time=2022-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218636, encodeId=dbeb12186364f, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8ba6319857, createdName=1064510_1039, createdTime=Wed May 11 07:03:26 CST 2022, time=2022-05-11, status=1, ipAttribution=)]
    2022-05-12 jichang
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content=与<a href='/topic/show?id=1e84103e7885' target=_blank style='color:#2F92EE;'>#**#</a>前相比,**早期和解封早期,STEMI院内死亡风险分别显著升高25%(OR 1.25,95%CI 1.16-1.34)和35%(OR 1.35,95%CI 1.21-1.50),并在解封晚期恢复到疫情前水平(OR 1.04,95%CI 0.95-1.14)。此外,按照<a href='/topic/show?id=dec589963c3' target=_blank style='color:#2F92EE;'>#血运重建#</a>方式及救治时间分层后,在疫情的五个阶段,<a href='/topic/show?id=1c6516e83b5' target=_blank style='color:#2F92EE;'>#STEMI#</a>患者呈现相同的死亡率梯度:无论是**期间还是解封后,接受PPCI治疗的患者死亡率均处于最低水平。 <a href='/topic/show?id=319443e22c5' target=_blank style='color:#2F92EE;'>#大数据#</a>的结果哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103778, encryptionId=1e84103e7885, topicName=**), TopicDto(id=89963, encryptionId=dec589963c3, topicName=血运重建), TopicDto(id=16783, encryptionId=1c6516e83b5, topicName=STEMI), TopicDto(id=43722, encryptionId=319443e22c5, topicName=大数据)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=赛华佗, createdTime=Wed May 11 08:04:29 CST 2022, time=2022-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218636, encodeId=dbeb12186364f, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8ba6319857, createdName=1064510_1039, createdTime=Wed May 11 07:03:26 CST 2022, time=2022-05-11, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=2008145, encodeId=8eff2008145dc, content=<a href='/topic/show?id=f244465139' target=_blank style='color:#2F92EE;'>#CHINA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4651, encryptionId=f244465139, topicName=CHINA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Mon Jun 13 03:15:43 CST 2022, time=2022-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1635258, encodeId=779f1635258bc, content=<a href='/topic/show?id=bb41983049e' target=_blank style='color:#2F92EE;'>#院内死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98304, encryptionId=bb41983049e, topicName=院内死亡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78f122436081, 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content=与<a href='/topic/show?id=1e84103e7885' target=_blank style='color:#2F92EE;'>#**#</a>前相比,**早期和解封早期,STEMI院内死亡风险分别显著升高25%(OR 1.25,95%CI 1.16-1.34)和35%(OR 1.35,95%CI 1.21-1.50),并在解封晚期恢复到疫情前水平(OR 1.04,95%CI 0.95-1.14)。此外,按照<a href='/topic/show?id=dec589963c3' target=_blank style='color:#2F92EE;'>#血运重建#</a>方式及救治时间分层后,在疫情的五个阶段,<a href='/topic/show?id=1c6516e83b5' target=_blank style='color:#2F92EE;'>#STEMI#</a>患者呈现相同的死亡率梯度:无论是**期间还是解封后,接受PPCI治疗的患者死亡率均处于最低水平。 <a href='/topic/show?id=319443e22c5' target=_blank style='color:#2F92EE;'>#大数据#</a>的结果哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103778, encryptionId=1e84103e7885, topicName=**), TopicDto(id=89963, encryptionId=dec589963c3, topicName=血运重建), TopicDto(id=16783, encryptionId=1c6516e83b5, topicName=STEMI), TopicDto(id=43722, encryptionId=319443e22c5, topicName=大数据)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=赛华佗, createdTime=Wed May 11 08:04:29 CST 2022, time=2022-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218636, encodeId=dbeb12186364f, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8ba6319857, createdName=1064510_1039, createdTime=Wed May 11 07:03:26 CST 2022, time=2022-05-11, status=1, ipAttribution=)]
    2022-05-12 xinmeili
  8. 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content=与<a href='/topic/show?id=1e84103e7885' target=_blank style='color:#2F92EE;'>#**#</a>前相比,**早期和解封早期,STEMI院内死亡风险分别显著升高25%(OR 1.25,95%CI 1.16-1.34)和35%(OR 1.35,95%CI 1.21-1.50),并在解封晚期恢复到疫情前水平(OR 1.04,95%CI 0.95-1.14)。此外,按照<a href='/topic/show?id=dec589963c3' target=_blank style='color:#2F92EE;'>#血运重建#</a>方式及救治时间分层后,在疫情的五个阶段,<a href='/topic/show?id=1c6516e83b5' target=_blank style='color:#2F92EE;'>#STEMI#</a>患者呈现相同的死亡率梯度:无论是**期间还是解封后,接受PPCI治疗的患者死亡率均处于最低水平。 <a href='/topic/show?id=319443e22c5' target=_blank style='color:#2F92EE;'>#大数据#</a>的结果哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103778, encryptionId=1e84103e7885, topicName=**), TopicDto(id=89963, encryptionId=dec589963c3, topicName=血运重建), TopicDto(id=16783, encryptionId=1c6516e83b5, topicName=STEMI), TopicDto(id=43722, encryptionId=319443e22c5, topicName=大数据)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=赛华佗, createdTime=Wed May 11 08:04:29 CST 2022, time=2022-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218636, encodeId=dbeb12186364f, content=<a href='/topic/show?id=46ce580e865' target=_blank style='color:#2F92EE;'>#新冠肺炎#</a>哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58078, encryptionId=46ce580e865, topicName=新冠肺炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8ba6319857, createdName=1064510_1039, createdTime=Wed May 11 07:03:26 CST 2022, time=2022-05-11, status=1, ipAttribution=)]
    2022-05-11 赛华佗

    #**#前相比,**早期和解封早期,STEMI院内死亡风险分别显著升高25%(OR 1.25,95%CI 1.16-1.34)和35%(OR 1.35,95%CI 1.21-1.50),并在解封晚期恢复到疫情前水平(OR 1.04,95%CI 0.95-1.14)。此外,按照#血运重建#方式及救治时间分层后,在疫情的五个阶段,#STEMI#患者呈现相同的死亡率梯度:无论是**期间还是解封后,接受PPCI治疗的患者死亡率均处于最低水平。 #大数据#的结果哦

    0

  9. 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channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16778, encryptionId=8cc416e78f3, topicName=STEM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1067833268, createdName=12498bb3m92(暂无昵称), createdTime=Thu May 12 13:15:43 CST 2022, time=2022-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1550873, encodeId=06e915508e3a8, content=<a href='/topic/show?id=f41c9890585' target=_blank style='color:#2F92EE;'>#霍勇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98905, encryptionId=f41c9890585, topicName=霍勇)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e95214139028, createdName=xinmeili, createdTime=Thu May 12 13:15:43 CST 2022, time=2022-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1218644, encodeId=e9cb12186443e, content=与<a href='/topic/show?id=1e84103e7885' target=_blank style='color:#2F92EE;'>#**#</a>前相比,**早期和解封早期,STEMI院内死亡风险分别显著升高25%(OR 1.25,95%CI 1.16-1.34)和35%(OR 1.35,95%CI 1.21-1.50),并在解封晚期恢复到疫情前水平(OR 1.04,95%CI 0.95-1.14)。此外,按照<a href='/topic/show?id=dec589963c3' target=_blank style='color:#2F92EE;'>#血运重建#</a>方式及救治时间分层后,在疫情的五个阶段,<a href='/topic/show?id=1c6516e83b5' target=_blank style='color:#2F92EE;'>#STEMI#</a>患者呈现相同的死亡率梯度:无论是**期间还是解封后,接受PPCI治疗的患者死亡率均处于最低水平。 <a href='/topic/show?id=319443e22c5' target=_blank style='color:#2F92EE;'>#大数据#</a>的结果哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103778, encryptionId=1e84103e7885, topicName=**), TopicDto(id=89963, encryptionId=dec589963c3, topicName=血运重建), TopicDto(id=16783, encryptionId=1c6516e83b5, topicName=STEMI), TopicDto(id=43722, encryptionId=319443e22c5, topicName=大数据)], attachment=null, authenticateStatus=null, 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