Chest:肺栓塞引起的院外心脏骤停复苏期间溶栓治疗可提高30天的生存率

2019-08-04 xing.T MedSci原创

由此可见,在确诊为PE且在住院期间自发循环恢复的OHCA患者中,CPR期间接受溶栓治疗的患者与未接受溶栓治疗的患者相比,30天生存率显著提高。

肺栓塞(PE)占所有院外心脏骤停(OHCA)原因的2%至5%,并且与极度不利的预后相关。在PE相关的OHCA中,不一致的数据显示心肺复苏(CPR)期间的溶栓可能有利于生存。

近日,呼吸领域权威杂志chest上发表了一篇研究文章,这是一项从2011年7月至2018年3月的回顾性、观察性、多中心研究。所有成年OHCA在入院时确诊为肺栓塞。主要终点是加权人群中的第30天存活率。

在入院的14253名患者中,328名最终诊断为PE,246名被纳入分析。在复苏期间接受溶栓治疗组(n=58)中,14例接受阿替普酶(24%),43例接受替奈普酶(74%)和1例接受链激酶(2%)。溶栓组30天生存率高于对照组(16% vs. 6%,P=0.005;调整对数秩检验),但良好的神经学结局无显著差异(10% vs. 5%;相对调整风险=1.97,95%CI为[0.70-5.56])。重症监护病房(ICU)的中位停留时间在溶栓组为1(0-5)天,对照组为1(0-3)天(P=0.23)。

由此可见,在确诊为PE且在住院期间自发循环恢复的OHCA患者中,CPR期间接受溶栓治疗的患者与未接受溶栓治疗的患者相比,30天生存率显著提高。 

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    2019-08-06 lizhou0204
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    2019-08-06 lqvr

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