JAHA:冠状动脉钙化快速进展的预测因素

2021-01-27 MedSci原创 MedSci原创

肾脏疾病、富含脂质的斑块和巨噬细胞是冠状动脉钙化快速进展的独立预测因子。基线时血管炎症和随后的稳定结果可能与钙化斑块快速进展有关。

冠状动脉钙化在血管事件和斑块稳定中的作用仍存在争议,并且尚未完全了解参与冠状动脉钙化进展的因素。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究旨在明确冠状动脉钙化快速发展的预测因素。

研究人员选择了在基线和6个月时进行连续光学相干断层扫描成像检查的患者,分析了钙化指数的变化和钙化进程的预测因子。钙化指数定义为平均钙化弧度与钙化长度的乘积。钙化的快速进展被定义为钙化指数的增加。

在187例进行连续光学相干断层扫描成像的患者中,基线时,105例(56.1%)患者发现了235个钙化斑块。6个月后,钙化指数在95.3%的钙化斑块中从132.0增加到178.2(P<0.001)。在多变量分析中,糖尿病(比值比[OR]为3.911;P<0.001)、慢性肾脏病(OR为2.432;P=0.037)、富含脂质的斑块(OR为2.698;P=0.034)和巨噬细胞(OR为6.782;P<0.001)是冠状动脉钙化快速进展的独立预测因子。有趣的是,钙化的快速进展与炎症显著减少有关(薄帽纤维状动脉瘤;从21.2%降至11.9%,P=0.003;巨噬细胞;从74.6%降至61.0%,P=0.001)。

由此可见,肾脏疾病、富含脂质的斑块和巨噬细胞是冠状动脉钙化快速进展的独立预测因子。基线时血管炎症和随后的稳定结果可能与钙化斑块快速进展有关

原始出处:

Akihiro Nakajima.et al.Predictors for Rapid Progression of Coronary Calcification: An Optical Coherence Tomography Study.J AM HEART ASSOC.2021.https://www.ahajournals.org/doi/10.1161/JAHA.120.019235

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    2021-10-17 ms2000001432825724

    怎么检测?

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attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Wed Jan 27 09:06:11 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264351, encodeId=2a161264351f6, content=<a href='/topic/show?id=daf1100226fb' target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Fri Jan 29 00:00:47 CST 2021, time=2021-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268402, encodeId=2db3126840224, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201110/2d55d24dc5fd419d994b7b920c79731b/d3c8bdca983c4af1b90220a8192e353a.jpg, createdBy=e14e5296465, createdName=飞翔的乌龟, createdTime=Wed Jan 27 09:14:14 CST 2021, time=2021-01-27, status=1, ipAttribution=)]
    展开3条回复
  5. [GetPortalCommentsPageByObjectIdResponse(id=1061303, encodeId=e5bc1061303cc, content=怎么检测?, beContent=null, objectType=article, channel=null, level=null, likeNumber=247, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c8d85638607, createdName=ms2000001432825724, createdTime=Sun Oct 17 21:09:54 CST 2021, time=2021-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1973533, encodeId=e66e19e3533c2, content=<a href='/topic/show?id=3e72309122a' target=_blank style='color:#2F92EE;'>#冠状动脉钙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30912, encryptionId=3e72309122a, topicName=冠状动脉钙)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/B389FA68ECBF51BE2FE14093CF61F6AE/100, createdBy=eb8e2500096, createdName=夏天与十三菇凉, createdTime=Fri Feb 05 21:00:47 CST 2021, time=2021-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1663306, encodeId=08b016633065e, content=<a href='/topic/show?id=4bae3334873' target=_blank style='color:#2F92EE;'>#动脉钙化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33348, encryptionId=4bae3334873, topicName=动脉钙化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3d1d25597695, createdName=1249897bm45(暂无昵称), createdTime=Sun Jun 06 12:00:47 CST 2021, time=2021-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920205, encodeId=e9cb92020558, content=<a href='/topic/show?id=974e51e2810' target=_blank style='color:#2F92EE;'>#心血管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=995, replyNumber=3, topicName=null, topicId=null, topicList=[TopicDto(id=51728, encryptionId=974e51e2810, topicName=心血管)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Wed Jan 27 09:06:11 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264351, encodeId=2a161264351f6, content=<a href='/topic/show?id=daf1100226fb' target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Fri Jan 29 00:00:47 CST 2021, time=2021-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1268402, encodeId=2db3126840224, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Fri Jan 29 00:00:47 CST 2021, time=2021-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269214, encodeId=adfc1269214ff, content=<a href='/topic/show?id=686830913f7' target=_blank style='color:#2F92EE;'>#冠状动脉钙化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30913, encryptionId=686830913f7, topicName=冠状动脉钙化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Fri Jan 29 00:00:47 CST 2021, time=2021-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920795, encodeId=6e8f920e9554, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=303, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e9485296624, createdName=ms4000000130239796, createdTime=Thu Jan 28 17:25:40 CST 2021, time=2021-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920472, encodeId=b5fb9204e2f6, content=进来看看学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=310, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200627/83a502bff6c14b759a7d0863b4068e7b/32ad40676056418ea58a94afac9c5b81.jpg, createdBy=6f475314305, createdName=水-晶, createdTime=Wed Jan 27 23:34:09 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920211, encodeId=78369202113c, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=312, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201110/2d55d24dc5fd419d994b7b920c79731b/d3c8bdca983c4af1b90220a8192e353a.jpg, createdBy=e14e5296465, createdName=飞翔的乌龟, createdTime=Wed Jan 27 09:14:14 CST 2021, time=2021-01-27, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1061303, encodeId=e5bc1061303cc, content=怎么检测?, beContent=null, objectType=article, channel=null, level=null, likeNumber=247, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c8d85638607, createdName=ms2000001432825724, createdTime=Sun Oct 17 21:09:54 CST 2021, time=2021-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1973533, encodeId=e66e19e3533c2, content=<a href='/topic/show?id=3e72309122a' target=_blank style='color:#2F92EE;'>#冠状动脉钙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30912, encryptionId=3e72309122a, topicName=冠状动脉钙)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/B389FA68ECBF51BE2FE14093CF61F6AE/100, createdBy=eb8e2500096, createdName=夏天与十三菇凉, createdTime=Fri Feb 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topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Fri Jan 29 00:00:47 CST 2021, time=2021-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1269214, encodeId=adfc1269214ff, content=<a href='/topic/show?id=686830913f7' target=_blank style='color:#2F92EE;'>#冠状动脉钙化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30913, encryptionId=686830913f7, topicName=冠状动脉钙化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Fri Jan 29 00:00:47 CST 2021, time=2021-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920795, encodeId=6e8f920e9554, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=303, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e9485296624, createdName=ms4000000130239796, createdTime=Thu Jan 28 17:25:40 CST 2021, time=2021-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920472, encodeId=b5fb9204e2f6, content=进来看看学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=310, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200627/83a502bff6c14b759a7d0863b4068e7b/32ad40676056418ea58a94afac9c5b81.jpg, createdBy=6f475314305, createdName=水-晶, createdTime=Wed Jan 27 23:34:09 CST 2021, time=2021-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=920211, encodeId=78369202113c, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=312, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201110/2d55d24dc5fd419d994b7b920c79731b/d3c8bdca983c4af1b90220a8192e353a.jpg, createdBy=e14e5296465, createdName=飞翔的乌龟, createdTime=Wed Jan 27 09:14:14 CST 2021, time=2021-01-27, status=1, ipAttribution=)]
    2021-01-29 zhaohui6731
  7. [GetPortalCommentsPageByObjectIdResponse(id=1061303, encodeId=e5bc1061303cc, content=怎么检测?, beContent=null, objectType=article, channel=null, level=null, likeNumber=247, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c8d85638607, createdName=ms2000001432825724, createdTime=Sun Oct 17 21:09:54 CST 2021, time=2021-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1973533, encodeId=e66e19e3533c2, content=<a href='/topic/show?id=3e72309122a' target=_blank style='color:#2F92EE;'>#冠状动脉钙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30912, encryptionId=3e72309122a, topicName=冠状动脉钙)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/B389FA68ECBF51BE2FE14093CF61F6AE/100, createdBy=eb8e2500096, createdName=夏天与十三菇凉, createdTime=Fri Feb 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  8. 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    2021-01-28 ms4000000130239796

    学习

    0

  9. 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    2021-01-27 水-晶

    进来看看学习了

    0

  10. 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    2021-01-27 飞翔的乌龟

    0

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