Circulation:血钠浓度高低均促慢肾病患者死亡

2012-01-25 MedSci MedSci原创

  美国学者的一项研究表明,在非透析依赖性慢性肾病患者中,无论是否存在充血性心力衰竭,血钠浓度较高和较低均与死亡率较高独立相关。论文于2012年1月5日在线发表于《循环》(Circulation)杂志。   在伴有充血性心力衰竭等疾病的患者中低钠血症较为常见,并且与住院患者死亡率升高相关。此项研究共纳入655493例非透析依赖性慢性肾病患者;利用时间相关Cox模型对潜在混淆因素进行校正,之后对血

  美国学者的一项研究表明,在非透析依赖性慢性肾病患者中,无论是否存在充血性心力衰竭,血钠浓度较高和较低均与死亡率较高独立相关。论文于2012年1月5日在线发表于《循环》(Circulation)杂志。

  在伴有充血性心力衰竭等疾病的患者中低钠血症较为常见,并且与住院患者死亡率升高相关。此项研究共纳入655493例非透析依赖性慢性肾病患者;利用时间相关Cox模型对潜在混淆因素进行校正,之后对血钠浓度与全因死亡率的相关性进行评估。

  结果显示,在中位5.5年随访期间共有193956例患者死亡(死亡率62.5/1000患者年)。血钠浓度与死亡率呈U形相关;血钠浓度为 140 mEq/l的患者死亡率最低,高于或低于此水平均与死亡率增加显著相关。与血钠浓度为136~145 mEq/l相比,血钠浓度<130、 130~135.9、145.1~150和≥150 mEq/l的多变量校正死亡危险比分别为1.93、1.28、1.33和 1.56(P<0.001)。在伴或不伴充血性心力衰竭的亚组患者中此相关性保持一致。

  链接:

  Hyponatremia, Hypernatremia and Mortality in Patients with Chronic Kidney Disease with and without Congestive Heart Failure 

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    2012-04-13 hmwwww
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