Clinical Nutrition: 地中海饮食减少了心血管高风险的患者动脉粥样硬化的形成

2020-11-17 MedSci原创 MedSci原创

循环微囊泡(cMV)是富含磷脂的小囊泡,有助于动脉粥样硬化形成过程,是心血管疾病(CVD)负担和进展的生物标志物。饮食是预防CVD的基石,但饮食对cMV脱落的影响的特征尚不明确。

背景与目标

循环微囊泡(cMV)是富含磷脂的小囊泡,有助于动脉粥样硬化形成过程,是血管疾病(CVD)负担和进展的生物标志物。饮食是预防CVD的基石,但饮食对cMV脱落的影响的特征尚不明确。本项研究旨在评估与低脂饮食(LFD)相比,地中海饮食对高心血管风险患者血液和血管腔室的MV脱落的长期影响。

 

 

方法

本项研究共有155名参与者,平均随访5年(53名患者在地中海饮食中补充了特级初榨橄榄油-EVOO;49名在地中海饮食中补充了新的橄榄油); 53名接受了LFD饮食)。在基线和一年的干预后,通过流式细胞术对cMV进行定量和表征分析,以通过膜联蛋白V(AV)结合来鉴定其活化的亲代细胞来源和血栓形成潜能。

 

 

结果

经过一年的饮食干预,与LFD和EVOO干预相比,坚果组的血小板源性淋巴细胞功能抑制因子PAC-1+ / AV+和淋巴细胞CD62P+ / AV+ cMV浓度较低( P = 0.036和0.003)。此外,地中海饮食干预措施中的血栓前cMV携带组织因子(CD142+ / AV+)和CD11a+ / AV+ cMV均比LFD低(P<0.0001和0.028)。

 

 

 

结论

cMV是似乎对饮食变化敏感的细胞活化和血管损伤的标志物。患者只要遵循富含EVOO或坚果的地中海饮食模式,就会产生伴有较低的细胞向动脉粥样硬化血栓形成前表型的活化因子。

 

在线免费使用:地中海饮食依从性评估(14点MeDiet得分)

原始出处:

Gemma Chiva-Blanch. Et al. The Mediterranean diet decreases prothrombotic microvesicle release in asymptomatic individuals at high cardiovascular risk. Clinical Nutrition.2020.

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    2020-11-18 weigq

    坚持地中海饮食方式!

    0

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    2020-11-18 健康达人

    地中海饮食是热点,被认为是最健康的饮食,而中国传统饮食一般被认为多半是不健康的,这是事实吗?其实需要更多严谨的科学证据,而不是猜测!

    0

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    2020-11-18 Jessica

    看来以后中午吃盒饭时,要加一点橄榄油了。

    0

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    2020-11-17 zll0628
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    2020-11-17 wgx311

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