BMJ Gastroenterology:食管切除术后体重严重减轻与食管癌患者5年生存率降低有关

2020-12-06 MedSci原创 MedSci原创

食道癌是全球第八大最常见的癌症。食道切除术是治疗食道癌的主要方法之一,但是,与其他胃肠外科手术相比,这是一种高度侵入性的手术。

      食道癌是全球第八大最常见的癌症。食道切除术是治疗食道癌的主要方法之一,但是,与其他胃肠外科手术相比,这是一种高度侵入性的手术。食道切除术后,许多患者的食欲和饮食摄入明显减少,从而导致严重的体重减轻。已经有研究证实术后营养不良与食管癌患者预后不良相关。因此,这项研究旨在评估术后严重体重减轻和通过空肠造口管(FT)进行肠内营养对食管切除术后长期预后的影响。

 

      这项研究纳入了2010年至2015年间在神户大学医院和兵库县癌症中心接受微创食管切除术的317例患者。在术后3个月对患者的体重进行了评估。将他们分为严重体重减轻(n = 65)和中等体重减轻(n = 252)组。此外,他们被分为FT组(184例在食管切除术中放置FT的患者)和非FT组(133例没有FT的患者)。再通过倾向评分匹配确定了FT组和no-FT组匹配的患者(每组119名)进行对照研究。

 

      研究结果显示严重减肥组的5年总生存率(OS)明显较低(p  = 0.024)。在多变量分析中,肿瘤浸润深度(pT3-4),术前治疗和严重体重减轻的OS较差(各个危险因素的危险比= 1.89; 95%可信区间= 1.12–3.17,危险比= 2.11; 95%可信区间= 1.25–3.54,危险比= 1.82; 95%置信区间分别为1.02-3.524)。FT组和非FT组在严重体重减轻患者和OS的数量上没有显着差异。

 

      本项研究证实严重的体重减轻与不良的OS密切相关。此外,通过FT进行肠内营养不能改善严重的体重减轻和OS。

 

 

原始出处:

Yasufumi Koterazawa. Et al. Severe weight loss after minimally invasive oesophagectomy is associated with poor survival in patients with oesophageal cancer at 5 years. BMJ Gastroenterology.2020.

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    2021-02-16 许安
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  5. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256798, encodeId=373f1256e9803, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Tue Dec 08 02:17:54 CST 2020, time=2020-12-08, status=1, ipAttribution=)]
    2021-06-15 ms4000001760817265

    受用

    0

  6. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1256798, encodeId=373f1256e9803, content=<a href='/topic/show?id=43706900963' target=_blank style='color:#2F92EE;'>#生存率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69009, encryptionId=43706900963, topicName=生存率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6a6043, createdName=guoyibin, createdTime=Tue Dec 08 02:17:54 CST 2020, time=2020-12-08, status=1, ipAttribution=)]
    2021-03-31 gaoxiaoe
  7. 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    2020-12-14 ms8000002045975899

    读书报告

    0

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