J Dermatolog Treat:点阵式二氧化碳激光疗法可有效改善烧伤造成的疤痕

2021-11-30 MedSci原创 MedSci原创

全世界有数百万人受到烧伤引起的疤痕的影响。一些研究报告了使用二氧化碳点阵激光治疗烧伤疤痕的结果,然而这些研究的结果各不相同,这一领域以前没有进行过系统的审查。

全世界有数百万人受到烧伤引起的疤痕的影响,这不仅是毁容,而且由于瘢痕挛缩、增生性变化和瘢痕疙瘩的形成影响了患者的生活质量。一些研究报告了使用二氧化碳点阵激光治疗烧伤疤痕的结果,然而这些研究的结果各不相同,这一领域以前没有进行过系统的审查。近日,发表于J Dermatolog Treat的一项荟萃分析了使用有效的评估工具评估二氧化碳点阵激光治疗烧伤疤痕的有效性的研究,以获得二氧化碳点阵激光治疗烧伤疤痕的综合证据。

研究人员在电子数据库中进行文献检索,并按照预先确定的资格标准选择研究。进行随机效应荟萃分析,以实现选定的疤痕评估量表分数和其他重要结果测量的变化(治疗后和治疗前的平均差异(MD))的效果大小。

 

结果,研究共纳入14项研究。分析结果显示,使用二氧化碳点阵激光治疗烧伤疤痕可显著改善温哥华疤痕量表(MD-3.01[95%置信区间(CI)-3.79,-2.22];p˂ .00001)、患者和观察者疤痕评估量表(POSAS)-患者(MD-14.38[95%CI-17. 62, -11.13]; p ˂ .00001,POSAS-观察者(MD -8.81 [9% CI -11.60, -6.02]; p ˂ .00001)以及疤痕评估量表(MD 1.64 [95% CI 0.49, 2.78]; p = .005)得分,尤其是在色素、血管、柔韧度以及疤痕高度方面的评分。疼痛和瘙痒症也在这种治疗中得到改善。用超声波测量的疤痕厚度下降不明显(MD -0.48 [95% CI -1.04, 0.09]; p = .1),而切割仪测量的R0(疤痕硬度)和R2(疤痕弹性)没有意义的变化。

综上所述,该研究结果表明,二氧化碳点阵激光疗法是治疗烧伤疤痕的重要工具,或可降低疤痕的严重程度。

 

原始出处:

 

Cong Zhang, et al., Efficacy of fractional carbon dioxide laser therapy for burn scars: a meta-analysis. J Dermatolog Treat. 2021 Nov;32(7):845-850. doi: 10.1080/09546634.2019.1704679.

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    2022-10-07 俅侠
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    2021-12-01 oliver169
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    2021-12-01 HinsMax
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    2021-12-01 fusion

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