Int Arch Allergy Immunol:成人过敏性鼻炎患者的肠道微生物类群的多样性降低且丰度改变

2020-10-25 AlexYang MedSci原创

特异的肠道微生物定植模式与婴儿过敏性疾病的发病有关;但没有足够的证据证明成年过敏性鼻炎(AR)患者是否仍旧存在异常的微生物组成模式。最近,有研究人员比较成年AR患者和对照组之间的肠道微生物组组成情况。

特异的肠道微生物定植模式与婴儿过敏性疾病的发病有关;但没有足够的证据证明成年过敏性鼻炎(AR)患者是否仍旧存在异常的微生物组成模式。最近,有研究人员比较成年AR患者和对照组之间的肠道微生物组组成情况。

研究人员比较了57名成年AR患者(39.06±13.29岁)和23名对照(CG;36.55±10.51岁)之间粪便样本中的肠道微生物组成情况。研究发现,与CG相比,通过Shannon指数确定的物种丰富度在AR队列中显著降低(AR:4.35±0.59 vs. CG:4.65±0.55,p=0.037);另外,还注意到操作分类单位(OTU)数目和逆辛普森以及CHAO1多样性指数存在减少趋势。拟杆菌(P=0.014)在AR组中的丰度明显高于CG组。相反,厚壁菌在AR组中的丰度显著低于CG组(p=0.006)。另外,与CG相比,AR组的副拟杆菌的丰度增加(p=0.008),草酸杆菌(p=0.001)和梭状芽孢杆菌(p=0.005)的丰度减少。

AR组和CG组细菌类群相对丰度

最后,研究人员指出,成年AR患者具有独特的肠道微生物组谱,与对照组相比,其特点是微生物多样性降低,某些微生物的丰度发生改变。他们的研究结果提供了成年AR患者独特的肠道微生物模式证据,且需要进一步的机理研究。

原始出处:

Annabelle M Watts , Nicholas P West , Ping Zhang et al. The Gut Microbiome of Adults with Allergic Rhinitis Is Characterised by Reduced Diversity and an Altered Abundance of Key Microbial Taxa Compared to Controls. Int Arch Allergy Immunol. Sep 2020

 

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    2020-10-27 膀胱癌
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    2020-10-25 ms3000000449926787

    多喝酸奶是不是也有治疗鼻炎的效果呢?

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