Infection:戊型肝炎病毒感染与精神分裂症的发生之间没有相关性

2022-06-21 xuyihan MedSci原创

戊型肝炎多数病例症状较轻,黄疸不很严重。治疗 适当休息、合理营养为主,选择性使用药物为辅。

感染戊型肝炎病毒 (HEV) 可能导致肝脏严重炎症,这也是世界上急性肝炎最常见的原因之一。据报道,肝外表现,如神经、血液或肾脏表现以及几种自身免疫现象与HEV感染有关。来自中国和德国的流行病学研究表明精神病患者的抗HEV IgG血清阳性率很高,然而,这些研究通常缺乏足够的对照组,因此难以对血清阳性率进行充分分类。

为此,研究人员收集了39名初步诊断为急性精神分裂症的患者。通过PCR 对所有患者的血清样本和脑脊液 (CSF) 进行HEV检测和抗 HEV IgG以确定该精神病患者队列中急性或既往HEV感染的患病率。急性精神分裂症的诊断是由专业的精神科医生确定的。患者年龄从18岁到52岁不等,平均年龄为31岁。39 名患者中有21名(54%)女性。女性个体的比例略高。

 

研究结果显示,35名患者 (90%) 的HEV血清免疫球蛋白 G (IgG) 检测呈阴性,在4名患者中发现 HEV IgG呈阳性 (10%),表明近期或之前感染了 HEV。男性抗HEV IgG的血清阳性率高于女性(22% VS 0%,p=0.01)。为了排除近期持续的HEV感染,研究人员在血清和CSF样本中进行了HEV聚合酶链反应 (PCR)。在任何血清或脑脊液样本中均未检测到 HEV 核糖核酸 (RNA)则定义为无HEV感染。

图:精神分裂症的危险因素

本项研究队列中的总体HEV IgG血清阳性率为10%。根据先前发表的队列,近年来德国健康对照组的HEV IgG血清阳性率范围为 15.3% 至 18.6%。与之前的研究不同,本项研究的数据库是在初步诊断时明确定义的急性精神分裂症患者队列中进行的。这些患者均未检测出HEV RNA阳性,与健康个体相比,血清阳性率也没有升高。因此,没有任何证据表明 HEV 感染的诊断与精神分裂症的急性发作之间存在关联,

原始出处:

Claudia Beisel. et al. No link between the prevalence of hepatitis E virus infection and the diagnosis of schizophrenia. Infection.2022.

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