Diabetes Care:2型糖尿病成人有氧运动能力的心血管决定因素

2020-07-19 MedSci原创 MedSci原创

在多民族的无症状T2D人群中,MPR和舒张功能是有氧运动能力的关键决定因素,与年龄、性别、民族、吸烟状况或血压无关。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,该研究旨在评估2型糖尿病(T2D)成人亚临床心脏功能障碍与有氧运动能力(峰值VO2)之间的关系。

在这项横断面研究中,研究人员前瞻性地招募了多民族的无症状T2D成人队列,他们无血管疾病病史、体征或症状。研究人员同时招募了年龄、性别和民族匹配的对照受试者进行比较。参与者接受了人体测量学分析,心肺运动测试以及核苷腺苷应激灌注成像的心血管磁共振检查。研究人员进行了多元线性回归分析,以确定心血管结构和功能与峰值VO2之间的独立关联。

该研究共有247名T2D成人(年龄为51.8±11.9岁,男性占55%,黑人或南亚人种占37%,HbA1c为7.4±1.1%[57±12 mmol/mol],糖尿病病程为61个月[32–120])和78名对照者。与对照者相比,T2D受试者的左室向心性重构增加,心肌灌注储备(MPR)降低,有氧运动能力显著降低(峰值VO2 18.0±6.6 vs. 27.8±9.0 mL/kg/min; P<0.001)。在包含年龄、性别、种族、吸烟状况和收缩压的多元线性回归模型中,只有MPR(β=0.822; P=0.006)和左心室舒张充盈压(E/e β=-0.388; P=0.001)与T2D患者的VO2峰值独立相关。

在多民族的无症状T2D人群中,MPR和舒张功能是有氧运动能力的关键决定因素,与年龄、性别、民族、吸烟状况或血压无关。

原始出处:

Gaurav S. Gulsin,.et al.Cardiovascular Determinants of Aerobic Exercise Capacity in Adults With Type 2 Diabetes.Diabetes Care.2020.https://doi.org/10.2337/dc20-0706

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    2020-07-19 misszhang

    谢谢MedSci提供最新的资讯

    0

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    2020-07-19 明天jing

    有氧运动与无氧运动应该一直有争议,二者对健康的作用有差别,但是也应该有度(时间)的关系,过度运动可能并不合适,尤其是无氧运动。

    0

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