Oxid Med Cell Longev:雷帕霉素或可让牙龈返老还童

2018-05-09 MedSci MedSci原创

老年牙周组织易受牙周病原体的影响,对炎症反应差,易发生肿瘤。通过连续复制培养的人牙龈成纤维细胞(hGFs)充当衰老的体外替代物进行研究。为了研究雷帕霉素(mTOR)抑制对牙龈老化的作用及机制靶标,研究人员使用雷帕霉素(20nmol/L)刺激hGFs 3天和30天。通过免疫荧光、实时PCR、ELISA、Western印迹和流式细胞术检查细胞和生物学变化。结果显示,对mTOR信号的抑制导致衰老相关的β

老年牙周组织易受牙周病原体的影响,对炎症反应差,易发生肿瘤。通过连续复制培养的人牙龈成纤维细胞(hGFs)充当衰老的体外替代物进行研究。

为了研究雷帕霉素(mTOR)抑制对牙龈老化的作用及机制靶标,研究人员使用雷帕霉素(20nmol/L)刺激hGFs 3天和30天。通过免疫荧光、实时PCR、ELISA、Western印迹和流式细胞术检查细胞和生物学变化。

结果显示,对mTOR信号的抑制导致衰老相关的β-半乳糖苷酶(SA-β-Gal-)阳性细胞较少,延迟了衰老的发生,保持了增殖能力并且降低了相关衰老的表达水平相关标志物,如p16INK4a、p21CIP1a、白细胞介素-6(IL-6)和IL-8。此外,牙周病原菌牙龈卟啉单胞菌(ATCC 33277)感染后,与对照组相比,mTOR预处理组降低了炎症细胞因子(IL-6和IL-8)的表达。mTOR抑制上调抗氧化成分(Cat、Sod2和Prdx3;P <0.05)的基因表达,并因此中和过量的活性氧(ROS)。

总之,我们的结果表明,mTOR的抑制作者用可能在一定程度上恢复衰老牙龈,并通过消除氧化应激来减轻炎症。

原始出处:

Xia Y, Sun M, et al., mTOR Inhibition Rejuvenates the Aging Gingival Fibroblasts through Alleviating Oxidative Stress. Oxid Med Cell Longev. 2017;2017:6292630. doi: 10.1155/2017/6292630. Epub 2017 Jul 19.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=892059, encodeId=dee3892059d2, content=<a href='/topic/show?id=73a8988297a' target=_blank style='color:#2F92EE;'>#雷帕霉素#</a>或可让<a href='/topic/show?id=79986e72382' target=_blank style='color:#2F92EE;'>#牙龈#</a>返老还童,事实上,对身体其它器官可能同样有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=174, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98829, encryptionId=73a8988297a, topicName=雷帕霉素), TopicDto(id=67723, encryptionId=79986e72382, topicName=牙龈)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed Oct 14 17:20:55 CST 2020, time=2020-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1960889, encodeId=7e3219608891d, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Sep 03 00:02:00 CST 2018, time=2018-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870620, encodeId=4ec318e062096, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu May 17 03:02:00 CST 2018, time=2018-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361635, encodeId=ef311361635ef, content=<a href='/topic/show?id=235c94324e2' target=_blank style='color:#2F92EE;'>#返老还童#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94324, encryptionId=235c94324e2, topicName=返老还童)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=40be178, createdName=zhyy88, createdTime=Fri May 11 11:02:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608809, encodeId=60dd160880924, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri May 11 11:02:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313902, encodeId=fff4313902c8, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6b0d1671629, createdName=1de11f7fm56(暂无匿称), createdTime=Thu May 10 21:59:40 CST 2018, time=2018-05-10, status=1, ipAttribution=)]
    2020-10-14 lovetcm

    #雷帕霉素#或可让#牙龈#返老还童,事实上,对身体其它器官可能同样有用

    0

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    2018-09-03 维他命
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  6. [GetPortalCommentsPageByObjectIdResponse(id=892059, encodeId=dee3892059d2, content=<a href='/topic/show?id=73a8988297a' target=_blank style='color:#2F92EE;'>#雷帕霉素#</a>或可让<a href='/topic/show?id=79986e72382' target=_blank style='color:#2F92EE;'>#牙龈#</a>返老还童,事实上,对身体其它器官可能同样有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=174, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98829, encryptionId=73a8988297a, topicName=雷帕霉素), TopicDto(id=67723, encryptionId=79986e72382, topicName=牙龈)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed Oct 14 17:20:55 CST 2020, time=2020-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1960889, encodeId=7e3219608891d, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Mon Sep 03 00:02:00 CST 2018, time=2018-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1870620, encodeId=4ec318e062096, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu May 17 03:02:00 CST 2018, time=2018-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361635, encodeId=ef311361635ef, content=<a href='/topic/show?id=235c94324e2' target=_blank style='color:#2F92EE;'>#返老还童#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94324, encryptionId=235c94324e2, topicName=返老还童)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=40be178, createdName=zhyy88, createdTime=Fri May 11 11:02:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1608809, encodeId=60dd160880924, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Fri May 11 11:02:00 CST 2018, time=2018-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313902, encodeId=fff4313902c8, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6b0d1671629, createdName=1de11f7fm56(暂无匿称), createdTime=Thu May 10 21:59:40 CST 2018, time=2018-05-10, status=1, ipAttribution=)]
    2018-05-10 1de11f7fm56(暂无匿称)

    学习了.谢谢分享

    0

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