NEJM:曲前列尼尔吸入治疗间质性肺炎肺动脉高压

2021-01-14 MedSci原创 MedSci原创

对于间质性肺炎肺动脉高压患者,曲前列尼尔吸入治疗可改善患者运动功能,提高6分钟步行测试距离

间质性肺炎是多种原因引起的肺间质炎性和纤维化疾病,而对于因间质性肺炎导致的肺动脉高压患者,目前尚无获批的治疗药物。近日研究人员考察了曲前列尼尔对间质性肺炎肺动脉高压患者的效果及安全性。
 
本次研究为多中心,随机,双盲,安慰剂对照研究,患有间质性肺炎并伴有肺动脉高压患者参与,随机接受曲前列尼尔吸入治疗,总剂量为72μg,每日分4次进行或安慰剂。研究的主要终点为16周6分钟步行测试距离较基线的变化,次要终点为氨基末端脑钠尿肽(NT-proBNP)水平及临床恶化。
 
326名患者参与研究,其中曲前列尼尔组163人,安慰剂组163人,组间基线特征相近。16周时,曲前列尼尔组与安慰剂组相比,6分钟步行距离与基线变化的最小二乘平均差异为31.12m。与基线相比,曲前列尼尔组NT-proBNP水平下降了15%,而安慰剂组上升46%。曲前列尼尔组37人出现临床恶化,而安慰剂组54人(22.7% vs 33.1%,HR=0.61)。最常见的不良事件包括咳嗽、头痛、呼吸困难、头晕、恶心、疲劳和腹泻。
 
研究认为,对于间质性肺炎肺动脉高压患者,曲前列尼尔吸入治疗可改善患者运动功能,提高6分钟步行测试距离
 
原始出处:
 
Aaron Waxman et al. Inhaled Treprostinil in Pulmonary Hypertension Due to Interstitial Lung Disease. N Engl J Med, January 13, 2021.

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    2021-01-20 周倪

    本次研究为多中心,随机,双盲,安慰剂对照研究,患有间质性肺炎并伴有肺动脉高压患者参与,随机接受曲前列尼尔吸入治疗,总剂量为72μg,每日分4次进行或安慰剂。研究的主要终点为16周6分钟步行测试距离较基线的变化,次要终点为氨基末端脑钠尿肽(NT-proBNP)水平及临床恶化。

    0

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    2021-01-20 skywalk3004

    学习

    0

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    2021-01-14 lifefamily

    #曲前列尼尔#吸入治疗#间质性肺炎##肺动脉高压#,不过仍然只是治标的药物

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  7. [GetPortalCommentsPageByObjectIdResponse(id=1925351, encodeId=fdeb192535134, content=<a href='/topic/show?id=26d633354c9' target=_blank style='color:#2F92EE;'>#动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33354, encryptionId=26d633354c9, topicName=动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Mon Jun 28 17:02:05 CST 2021, time=2021-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815830, encodeId=9bfe181583057, content=<a href='/topic/show?id=82e99e291b0' target=_blank style='color:#2F92EE;'>#间质性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97291, encryptionId=82e99e291b0, topicName=间质性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99cf2500102, createdName=zjshifan_98647306, createdTime=Mon May 24 03:02:05 CST 2021, time=2021-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918460, encodeId=fd739184602b, content=本次研究为多中心,随机,双盲,安慰剂对照研究,患有间质性肺炎并伴有肺动脉高压患者参与,随机接受曲前列尼尔吸入治疗,总剂量为72μg,每日分4次进行或安慰剂。研究的主要终点为16周6分钟步行测试距离较基线的变化,次要终点为氨基末端脑钠尿肽(NT-proBNP)水平及临床恶化。, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=83d65159431, createdName=周倪, createdTime=Wed Jan 20 16:22:37 CST 2021, time=2021-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918412, encodeId=f7f291841288, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210119/c927ceda7130411b9f6039935627a2e6/4c85aa535b1b459ea6166ab0917ee636.jpg, createdBy=418b3050927, createdName=skywalk3004, createdTime=Wed Jan 20 14:54:09 CST 2021, time=2021-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=916634, encodeId=6b6991663483, content=<a href='/topic/show?id=70e8602218d' target=_blank style='color:#2F92EE;'>#曲前列尼尔#</a>吸入治疗<a href='/topic/show?id=14b99e293ea' target=_blank style='color:#2F92EE;'>#间质性肺炎#</a><a href='/topic/show?id=0bad820e112' target=_blank style='color:#2F92EE;'>#肺动脉高压#</a>,不过仍然只是治标的药物, beContent=null, objectType=article, channel=null, level=null, likeNumber=269, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60221, encryptionId=70e8602218d, topicName=曲前列尼尔), TopicDto(id=97293, encryptionId=14b99e293ea, topicName=间质性肺炎), TopicDto(id=82071, encryptionId=0bad820e112, topicName=肺动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=lifefamily, createdTime=Thu Jan 14 21:30:44 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=916586, encodeId=480891658656, content=<a href='/topic/show?id=ac36104141fb' target=_blank style='color:#2F92EE;'>#间质性肺炎肺动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104141, encryptionId=ac36104141fb, topicName=间质性肺炎肺动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Thu Jan 14 17:23:33 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035554, encodeId=54ee1035554b5, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Jan 14 15:02:05 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050914, encodeId=d0d410509145f, content=肺动脉高压表面是罕见病,事实上临床上并不少见,治疗药物虽然有一些,但是整体仍然不理解,可能未来需要采用综合治疗措施。, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Thu Jan 14 15:02:05 CST 2021, time=2021-01-14, status=1, ipAttribution=)]
    2021-01-14 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1925351, encodeId=fdeb192535134, content=<a href='/topic/show?id=26d633354c9' target=_blank style='color:#2F92EE;'>#动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33354, encryptionId=26d633354c9, topicName=动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Mon Jun 28 17:02:05 CST 2021, time=2021-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1815830, encodeId=9bfe181583057, content=<a href='/topic/show?id=82e99e291b0' target=_blank style='color:#2F92EE;'>#间质性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97291, encryptionId=82e99e291b0, topicName=间质性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99cf2500102, createdName=zjshifan_98647306, createdTime=Mon May 24 03:02:05 CST 2021, time=2021-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918460, encodeId=fd739184602b, content=本次研究为多中心,随机,双盲,安慰剂对照研究,患有间质性肺炎并伴有肺动脉高压患者参与,随机接受曲前列尼尔吸入治疗,总剂量为72μg,每日分4次进行或安慰剂。研究的主要终点为16周6分钟步行测试距离较基线的变化,次要终点为氨基末端脑钠尿肽(NT-proBNP)水平及临床恶化。, beContent=null, objectType=article, channel=null, level=null, likeNumber=159, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=83d65159431, createdName=周倪, createdTime=Wed Jan 20 16:22:37 CST 2021, time=2021-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=918412, encodeId=f7f291841288, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210119/c927ceda7130411b9f6039935627a2e6/4c85aa535b1b459ea6166ab0917ee636.jpg, createdBy=418b3050927, createdName=skywalk3004, createdTime=Wed Jan 20 14:54:09 CST 2021, time=2021-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=916634, encodeId=6b6991663483, content=<a href='/topic/show?id=70e8602218d' target=_blank style='color:#2F92EE;'>#曲前列尼尔#</a>吸入治疗<a href='/topic/show?id=14b99e293ea' target=_blank style='color:#2F92EE;'>#间质性肺炎#</a><a href='/topic/show?id=0bad820e112' target=_blank style='color:#2F92EE;'>#肺动脉高压#</a>,不过仍然只是治标的药物, beContent=null, objectType=article, channel=null, level=null, likeNumber=269, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=60221, encryptionId=70e8602218d, topicName=曲前列尼尔), TopicDto(id=97293, encryptionId=14b99e293ea, topicName=间质性肺炎), TopicDto(id=82071, encryptionId=0bad820e112, topicName=肺动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211210/ede9c51184aa4f54ae6c1164cfb8eeac/967dbf3eff2943c7bf3ccfec3a776ab0.JPG, createdBy=a33789389, createdName=lifefamily, createdTime=Thu Jan 14 21:30:44 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=916586, encodeId=480891658656, content=<a href='/topic/show?id=ac36104141fb' target=_blank style='color:#2F92EE;'>#间质性肺炎肺动脉高压#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104141, encryptionId=ac36104141fb, topicName=间质性肺炎肺动脉高压)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Thu Jan 14 17:23:33 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035554, encodeId=54ee1035554b5, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Thu Jan 14 15:02:05 CST 2021, time=2021-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1050914, encodeId=d0d410509145f, content=肺动脉高压表面是罕见病,事实上临床上并不少见,治疗药物虽然有一些,但是整体仍然不理解,可能未来需要采用综合治疗措施。, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=明天jing, createdTime=Thu Jan 14 15:02:05 CST 2021, time=2021-01-14, status=1, ipAttribution=)]
    2021-01-14 明天jing

    肺动脉高压表面是罕见病,事实上临床上并不少见,治疗药物虽然有一些,但是整体仍然不理解,可能未来需要采用综合治疗措施。

    0

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Cardiovasc Ther:华法林对曲前列尼尔治疗的肺动脉高压患者生存率有影响吗?

2017年10月,发表在《Cardiovasc Ther》上的一项研究,考查了接受皮下注射曲前列尼尔的肺动脉高压(PAH)患者中华法林对生存率的影响。研究结果证实:长期使用华法林抗凝对皮下注射(SQ)曲前列尼尔治疗的PAH或先天性肺动脉高压(IPAH)患者生存率没有任何显着作用。

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