Eur Respir J:阻塞性睡眠呼吸暂停是发生代谢综合征的危险因素

2018-11-09 xing.T MedSci原创

由此可见,在一般人群中通过调节夜间低氧血症,OSA与发生MetS风险增加独立相关。

横断面研究表明阻塞性睡眠呼吸暂停(OSA)与代谢综合征(MetS)之间存在相关性,但是否存在时间关系尚不清楚。近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,研究人员旨在研究OSA对一般人群MetS风险的影响。

这项前瞻性研究结合了两个基于人群的样本:Episono(巴西)和HypnoLaus(瑞士)样本。根据统一标准评估MetS。对Episono样本在基线和随访期间以及HypnoLaus样本基线时进行了多导睡眠图(PSG)检查。OSA根据呼吸暂停-低通气指数定义为轻度(5-15次事件每小时)和中度至重度(≥15次事件每小时)。

研究人员纳入了1853名参与者(年龄平均值±SD为52±13岁,56%为女性),基线时没有MetS。平均±SD为6±1年后,318名(17.2%)参与者发展为MetS。中度至重度OSA与MetS事件独立相关(OR为2.58,95%CI为1.61-4.11),通过调节动脉血氧饱和度<90%的时间百分比,MetS组分从基线到随访的数量增加。Episono样本中的亚组分析证实,基线和随访之间PSG该参数的增加代表了MetS事件的危险因素(每增加10%,OR为1.42,95%CI为1.04-1.95)。

由此可见,在一般人群中通过调节夜间低氧血症,OSA与发生MetS风险增加独立相关。

原始出处:

Camila Hirotsu,et al.Obstructive sleep apnoea as a risk factor for incident metabolic syndrome: a joined Episono and HypnoLaus prospective cohorts study.Eur Respir J.2018. http://erj.ersjournals.com/content/52/5/1801150

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    2018-11-09 flysky120

    学习知识了谢谢

    0

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    2018-11-09 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

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    2018-11-09 龙胆草

    学习谢谢分享

    0

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由此可见,该临床研究采用非侵入性示波法测量确定了快速眼动睡眠和严重氧饱和度下降对OSA相关血压升高的影响。

Eur Respir J:持续气道正压对2型糖尿病合并阻塞性睡眠呼吸暂停患者视力的影响

与12个月以上的常规护理相比,采用CPAP治疗OSA并未改善2型糖尿病合并DMO患者的视力。

Eur Respir J:身体活动是阻塞性睡眠呼吸暂停和心脏代谢风险的调节因素

由此可见,体力活动是预防OSA患者2型糖尿病的保护性因素;此外,经常性体力活动降低了发生OSA的风险,并且与更好的心脏代谢特征有关。

Chest:OSA和心血管疾病合并症患者长期使用CPAP对体重的影响

由此可见,同时患有OSA和心血管疾病的患者长期使用CPAP不会导致临床显著的体重变化。

J Oral Rehabil:经鼻咽气道支架治疗 OSA可被改善

日本的一项研究显示,鼻咽气道支架(Nastent)装置可以改善阻塞性睡眠呼吸暂停(OSA),这预示着与下咽部相比,较窄的腭咽部对治疗反映出良好的敏感性和特异性。该论文10月3日在线发表于《口腔康复学杂志》(J Oral Rehabil)。

Chest:慢性鼻窦炎是世贸中心救援者阻塞性睡眠呼吸暂停的独立危险因素

由此可见,肥胖和性别没有充分解释WTC救援者中OSA的高患病率。CRS受试者OSA风险升高的可能机制包括上呼吸道炎症增加和/或鼻部/上呼吸道阻力升高,但需要进一步确认。