J Diabetes Investig:代谢综合征增加糖尿病前期患者心血管风险

2018-12-09 国际糖尿病编辑部 国际糖尿病

一项最新研究结果显示,在中国成人糖尿病前期患者中,代谢综合征使主要心血管事件发生风险增加。

一项最新研究结果显示,在中国成人糖尿病前期患者中,代谢综合征使主要血管事件发生风险增加。

研究者汕头大学医学院第二附属医院血管内科陈有仁教授等人在文中写道,糖尿病前期被认为是心血管并发症增加的危险因素。因此,在糖尿病前期患者中筛查管理高危人群将更具成本效益。此外,糖尿病前期通常伴有更广泛的潜在疾病表现,包括代谢综合征

研究者开展了一项前瞻性社区队列研究,对2006年6月~2007年10月中国北方一个社区参与两年一次健康检查的19 464例糖尿病前期患者(平均年龄52岁,14.4%为女性)数据进行了分析。对受试者中位随访10年,评估主要心血管事件包括非致死性心肌梗死卒中的首发情况。

在该队列中,有1169例(6%)患者发生心血管事件(95%CI:5.6~6.3)。与15 775例无代谢综合征的患者相比,3689例有代谢综合征的成人主要心血管事件发生率显著升高(9% vs. 5.3%)。对于卒中和心肌梗死也如此,其在有代谢综合征的患者中发生率分别为6.8%和2.5%,在无代谢综合征的患者中发生率分别为4.3%和1.2%。

研究者表示,他们发现有代谢综合征的受试者心肌梗死、卒中或心血管疾病的发生风险明显增加。该研究结果丰富了中国糖尿病前期人群中代谢综合征与不良结局之间关系的证据,有助于筛查糖尿病前期人群中的高危人群,从而制定相应的预防策略。

在考虑其他因素如年龄、性别、吸烟状态、饮酒、收入、教育程度、肾损伤、脂肪肝、心率和高敏C反应蛋白等之后,与无代谢综合征的患者相比,有代谢综合征的患者发生主要心血管事件的风险更高(HR 1.5;95%CI:1.31~1.73)。

基于糖尿病前期与代谢综合征之间的关系,研究者建议对这类患者进行危险分层,同时改变生活方式,增加体力活动和减重7%,药物治疗则被视为次要治疗策略。

研究者写道,糖尿病前期和代谢综合征的高发不仅突出了常规评估糖尿病前期患者代谢综合征的重要性,还表明这两种情况可能有共同的代谢土壤,其中肥胖和胰岛素抵抗是常见因素。

原始出处:
Zekai Chen  Shouling Wu  Jianhuan Huang, et al. Metabolic syndrome increases cardiovascular risk in a population with prediabetes: A prospective study in a cohort of Chinese adults. Journal of Diabetes Investigation. Oct 2018.

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    2019-06-08 hb2008ye
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    2018-12-27 荒郊野树

    Iycotfitct

    0

  7. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq08fBE4ne4yAYXulsHUXiafWXWEQ1kDkMHtT9loagc1nibPCrwjpESVuPO4De8QTeajAic31lDPfjuA/132, createdBy=92ce1931739, createdName=荒郊野树, createdTime=Thu Dec 27 06:59:04 CST 2018, time=2018-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=356430, encodeId=f768356430b2, content=恶略不搭噶, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq08fBE4ne4yAYXulsHUXiafWXWEQ1kDkMHtT9loagc1nibPCrwjpESVuPO4De8QTeajAic31lDPfjuA/132, createdBy=92ce1931739, createdName=荒郊野树, createdTime=Wed Dec 26 06:50:46 CST 2018, time=2018-12-26, status=1, ipAttribution=), 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createdName=荒郊野树, createdTime=Wed Dec 19 06:52:14 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431393, encodeId=d1291431393cc, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Dec 11 10:01:00 CST 2018, time=2018-12-11, status=1, ipAttribution=)]
    2018-12-26 荒郊野树

    恶略不搭噶

    0

  8. 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createdName=荒郊野树, createdTime=Wed Dec 19 06:52:14 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431393, encodeId=d1291431393cc, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Dec 11 10:01:00 CST 2018, time=2018-12-11, status=1, ipAttribution=)]
    2018-12-20 荒郊野树

    let觉JS

    0

  9. 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createdName=荒郊野树, createdTime=Wed Dec 19 06:52:14 CST 2018, time=2018-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431393, encodeId=d1291431393cc, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Dec 11 10:01:00 CST 2018, time=2018-12-11, status=1, ipAttribution=)]
    2018-12-19 荒郊野树

    哦热了热绝交热areas

    0

  10. 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