J Neuroimmunol:研究发现Th17/Treg细胞失衡参与了自闭症谱系障碍的发生

2020-10-03 MedSci原创 MedSci原创

本研究旨在调查Th17/Treg细胞失衡可能参与自闭症谱系障碍(ASD),研究结果已在线发表于J Neuroimmunol。

本研究旨在调查Th17/Treg细胞失衡可能参与自闭症谱系障碍(ASD),研究结果已在线发表于J Neuroimmunol。

使用流式细胞仪测定循环Th17和Treg细胞百分比,使用RT- PCR和ELISA检测细胞因子的表达。结果显示,ASD儿童的Th17/Treg平衡与对照组相比明显偏向Th17反应。Th17细胞和Th17/Treg细胞的比例与疾病严重程度呈明显的正相关,而Treg细胞则呈负相关。

 

综上所述,该研究结果表明,Th17、Treg细胞及其相关细胞因子的失衡可能在疾病的进展中起着至关重要的作用。

 

原始出处:

 

Mai MoaazSara Youssry, et al., Th17/Treg cells imbalance and their related cytokines (IL-17, IL-10 and TGF-β) in children with autism spectrum disorder. J Neuroimmunol. 2019 Dec 15;337:577071. doi: 10.1016/j.jneuroim.2019.577071.

 

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    2020-10-05 zhaojie88
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    2020-10-05 xiongke014

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