Clin Nutrition:低同型半胱氨酸血症可能会增加患痴呆症和阿尔茨海默病的风险

2021-06-18 MedSci原创 MedSci原创

同型半胱氨酸是一种由营养蛋氨酸去甲基化形成的氨基酸,它参与多种代谢过程,包括甲基化和硫化反应。

       同型半胱氨酸是一种由营养蛋氨酸去甲基化形成的氨基酸,它参与多种代谢过程,包括甲基化和硫化反应。高同型半胱氨酸血症会增加β-淀粉样蛋白的产生并抑制细胞系中血管内皮细胞的生长,大多数前瞻性队列研究表明,高同型半胱氨酸血症会增加人类患痴呆症的风险。

 

      最近的一项研究报告表明,维生素 B 补充剂是一种降低同型半胱氨酸的药物。然而,关于血液同型半胱氨酸水平可以降低到什么程度的研究很少。在人体中,低同型半胱氨酸血症可能会降低 DNA 甲基化程度,并增加其对氧化应激的敏感性。如果低同型半胱氨酸血症会增加患痴呆症的风险,那么误用或过度使用降低同型半胱氨酸的药物(如维生素补充剂)可能会增加患痴呆症的风险。因此,本项研究旨在探究低同型半胱氨酸血症是否会增加大型老年人群患痴呆症和阿尔茨海默病 (AD) 的风险。

 

      本项研究为一项前瞻性队列研究,研究人员对 2010 年至 2018 年 60 岁或以上的 2655 名的非痴呆个体进行了长期随访。对患者们的血清总同型半胱氨酸 (tHcy) 水平进行了测量,并检查了血清 tHcy 对痴呆和痴呆风险的影响。

 

 

      在随访期间,分别有 85 名和 64 名参与者出现痴呆和 AD。与血清 tHcy 水平在 9.0 之间的参与者相比,血清 tHcy 高(≥10.6 μmol/L)的参与者和血清 tHcy 低(≤8.9 μmol/L)的参与者患痴呆症和 AD 的可能性都要更高(高 4-5 倍)。随着血清tHcy浓度的升高,维生素补充剂的使用减少,41.2%的低血清tHcy(≤8.9 μmol/L)参与者正在服用维生素补充剂。

图:阿尔兹海默症的危险因素

      本项研究证实不仅高同型半胱氨酸血症会增加老年人患痴呆症和 AD 的风险,而且低同型半胱氨酸血症也会显着增加老年人患痴呆症和 AD 的风险。

 

 

原始出处:

Jong Bin Bae. Et al. Hypohomocysteinemia may increases the risk of dementia and Alzheimer's disease: A nationwide population-based prospective cohort study. Clinical Nutrition.2021.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (7)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2118412, encodeId=2dec21184122e, content=<a href='/topic/show?id=b730105511d0' target=_blank style='color:#2F92EE;'>#低同型半胱氨酸血症#</a>可能会增加患<a href='/topic/show?id=18b3e120514' target=_blank style='color:#2F92EE;'>#痴呆#</a>症和<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a>的风险,这个如何解释?<a href='/topic/show?id=3522389386f' target=_blank style='color:#2F92EE;'>#同型半胱氨酸#</a>高了不好,低了也不好?, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=105511, encryptionId=b730105511d0, topicName=低同型半胱氨酸血症), TopicDto(id=71205, encryptionId=18b3e120514, topicName=痴呆), TopicDto(id=97789, encryptionId=3cbe9e7892e, topicName=阿尔茨海默病), TopicDto(id=38938, encryptionId=3522389386f, topicName=同型半胱氨酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Thu Mar 09 04:30:37 CST 2023, time=2023-03-09, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=1817092, encodeId=c441181e0927d, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Sat Jan 01 21:23:22 CST 2022, time=2022-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836264, encodeId=ad011836264d5, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Sun Aug 22 22:23:22 CST 2021, time=2021-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661642, encodeId=c46e16616422e, content=<a href='/topic/show?id=1b3c1315481' target=_blank style='color:#2F92EE;'>#nutrition#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13154, encryptionId=1b3c1315481, topicName=nutrition)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0d25331316, createdName=膀胱癌, createdTime=Mon May 09 20:23:22 CST 2022, time=2022-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1818115, encodeId=bdf71818115c4, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Tue Nov 02 18:23:22 CST 2021, time=2021-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1470469, encodeId=b7dc14e046928, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Sun Jun 20 01:23:22 CST 2021, time=2021-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048807, encodeId=d670104880ea1, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Fri Jun 18 13:23:22 CST 2021, time=2021-06-18, status=1, ipAttribution=)]
    2023-03-09 showtest 来自上海

    #低同型半胱氨酸血症#可能会增加患#痴呆#症和#阿尔茨海默病#的风险,这个如何解释?#同型半胱氨酸#高了不好,低了也不好?

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2118412, encodeId=2dec21184122e, content=<a href='/topic/show?id=b730105511d0' target=_blank style='color:#2F92EE;'>#低同型半胱氨酸血症#</a>可能会增加患<a href='/topic/show?id=18b3e120514' target=_blank style='color:#2F92EE;'>#痴呆#</a>症和<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a>的风险,这个如何解释?<a href='/topic/show?id=3522389386f' target=_blank style='color:#2F92EE;'>#同型半胱氨酸#</a>高了不好,低了也不好?, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=105511, encryptionId=b730105511d0, topicName=低同型半胱氨酸血症), TopicDto(id=71205, encryptionId=18b3e120514, topicName=痴呆), TopicDto(id=97789, encryptionId=3cbe9e7892e, topicName=阿尔茨海默病), TopicDto(id=38938, encryptionId=3522389386f, topicName=同型半胱氨酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Thu Mar 09 04:30:37 CST 2023, time=2023-03-09, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=1817092, encodeId=c441181e0927d, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Sat Jan 01 21:23:22 CST 2022, time=2022-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836264, encodeId=ad011836264d5, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Sun Aug 22 22:23:22 CST 2021, time=2021-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661642, encodeId=c46e16616422e, content=<a href='/topic/show?id=1b3c1315481' target=_blank style='color:#2F92EE;'>#nutrition#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13154, encryptionId=1b3c1315481, topicName=nutrition)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0d25331316, createdName=膀胱癌, createdTime=Mon May 09 20:23:22 CST 2022, time=2022-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1818115, encodeId=bdf71818115c4, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Tue Nov 02 18:23:22 CST 2021, time=2021-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1470469, encodeId=b7dc14e046928, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Sun Jun 20 01:23:22 CST 2021, time=2021-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048807, encodeId=d670104880ea1, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Fri Jun 18 13:23:22 CST 2021, time=2021-06-18, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=2118412, encodeId=2dec21184122e, content=<a href='/topic/show?id=b730105511d0' target=_blank style='color:#2F92EE;'>#低同型半胱氨酸血症#</a>可能会增加患<a href='/topic/show?id=18b3e120514' target=_blank style='color:#2F92EE;'>#痴呆#</a>症和<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a>的风险,这个如何解释?<a href='/topic/show?id=3522389386f' target=_blank style='color:#2F92EE;'>#同型半胱氨酸#</a>高了不好,低了也不好?, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=105511, encryptionId=b730105511d0, topicName=低同型半胱氨酸血症), TopicDto(id=71205, encryptionId=18b3e120514, topicName=痴呆), TopicDto(id=97789, encryptionId=3cbe9e7892e, topicName=阿尔茨海默病), TopicDto(id=38938, encryptionId=3522389386f, topicName=同型半胱氨酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Thu Mar 09 04:30:37 CST 2023, time=2023-03-09, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=1817092, encodeId=c441181e0927d, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Sat Jan 01 21:23:22 CST 2022, time=2022-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836264, encodeId=ad011836264d5, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Sun Aug 22 22:23:22 CST 2021, time=2021-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661642, encodeId=c46e16616422e, content=<a href='/topic/show?id=1b3c1315481' target=_blank style='color:#2F92EE;'>#nutrition#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13154, encryptionId=1b3c1315481, topicName=nutrition)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0d25331316, createdName=膀胱癌, createdTime=Mon May 09 20:23:22 CST 2022, time=2022-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1818115, encodeId=bdf71818115c4, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Tue Nov 02 18:23:22 CST 2021, time=2021-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1470469, encodeId=b7dc14e046928, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Sun Jun 20 01:23:22 CST 2021, time=2021-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048807, encodeId=d670104880ea1, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Fri Jun 18 13:23:22 CST 2021, time=2021-06-18, status=1, ipAttribution=)]
    2021-08-22 Boyinsh
  4. [GetPortalCommentsPageByObjectIdResponse(id=2118412, encodeId=2dec21184122e, content=<a href='/topic/show?id=b730105511d0' target=_blank style='color:#2F92EE;'>#低同型半胱氨酸血症#</a>可能会增加患<a href='/topic/show?id=18b3e120514' target=_blank style='color:#2F92EE;'>#痴呆#</a>症和<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a>的风险,这个如何解释?<a href='/topic/show?id=3522389386f' target=_blank style='color:#2F92EE;'>#同型半胱氨酸#</a>高了不好,低了也不好?, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=105511, encryptionId=b730105511d0, topicName=低同型半胱氨酸血症), TopicDto(id=71205, encryptionId=18b3e120514, topicName=痴呆), TopicDto(id=97789, encryptionId=3cbe9e7892e, topicName=阿尔茨海默病), TopicDto(id=38938, encryptionId=3522389386f, topicName=同型半胱氨酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Thu Mar 09 04:30:37 CST 2023, time=2023-03-09, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=1817092, encodeId=c441181e0927d, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Sat Jan 01 21:23:22 CST 2022, time=2022-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836264, encodeId=ad011836264d5, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Sun Aug 22 22:23:22 CST 2021, time=2021-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661642, encodeId=c46e16616422e, content=<a href='/topic/show?id=1b3c1315481' target=_blank style='color:#2F92EE;'>#nutrition#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13154, encryptionId=1b3c1315481, topicName=nutrition)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0d25331316, createdName=膀胱癌, createdTime=Mon May 09 20:23:22 CST 2022, time=2022-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1818115, encodeId=bdf71818115c4, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Tue Nov 02 18:23:22 CST 2021, time=2021-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1470469, encodeId=b7dc14e046928, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Sun Jun 20 01:23:22 CST 2021, time=2021-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048807, encodeId=d670104880ea1, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Fri Jun 18 13:23:22 CST 2021, time=2021-06-18, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=2118412, encodeId=2dec21184122e, content=<a href='/topic/show?id=b730105511d0' target=_blank style='color:#2F92EE;'>#低同型半胱氨酸血症#</a>可能会增加患<a href='/topic/show?id=18b3e120514' target=_blank style='color:#2F92EE;'>#痴呆#</a>症和<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a>的风险,这个如何解释?<a href='/topic/show?id=3522389386f' target=_blank style='color:#2F92EE;'>#同型半胱氨酸#</a>高了不好,低了也不好?, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=105511, encryptionId=b730105511d0, topicName=低同型半胱氨酸血症), TopicDto(id=71205, encryptionId=18b3e120514, topicName=痴呆), TopicDto(id=97789, encryptionId=3cbe9e7892e, topicName=阿尔茨海默病), TopicDto(id=38938, encryptionId=3522389386f, topicName=同型半胱氨酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Thu Mar 09 04:30:37 CST 2023, time=2023-03-09, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=1817092, encodeId=c441181e0927d, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Sat Jan 01 21:23:22 CST 2022, time=2022-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836264, encodeId=ad011836264d5, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Sun Aug 22 22:23:22 CST 2021, time=2021-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661642, encodeId=c46e16616422e, content=<a href='/topic/show?id=1b3c1315481' target=_blank style='color:#2F92EE;'>#nutrition#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13154, encryptionId=1b3c1315481, topicName=nutrition)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0d25331316, createdName=膀胱癌, createdTime=Mon May 09 20:23:22 CST 2022, time=2022-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1818115, encodeId=bdf71818115c4, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Tue Nov 02 18:23:22 CST 2021, time=2021-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1470469, encodeId=b7dc14e046928, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Sun Jun 20 01:23:22 CST 2021, time=2021-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048807, encodeId=d670104880ea1, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Fri Jun 18 13:23:22 CST 2021, time=2021-06-18, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2118412, encodeId=2dec21184122e, content=<a href='/topic/show?id=b730105511d0' target=_blank style='color:#2F92EE;'>#低同型半胱氨酸血症#</a>可能会增加患<a href='/topic/show?id=18b3e120514' target=_blank style='color:#2F92EE;'>#痴呆#</a>症和<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a>的风险,这个如何解释?<a href='/topic/show?id=3522389386f' target=_blank style='color:#2F92EE;'>#同型半胱氨酸#</a>高了不好,低了也不好?, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=105511, encryptionId=b730105511d0, topicName=低同型半胱氨酸血症), TopicDto(id=71205, encryptionId=18b3e120514, topicName=痴呆), TopicDto(id=97789, encryptionId=3cbe9e7892e, topicName=阿尔茨海默病), TopicDto(id=38938, encryptionId=3522389386f, topicName=同型半胱氨酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Thu Mar 09 04:30:37 CST 2023, time=2023-03-09, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=1817092, encodeId=c441181e0927d, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Sat Jan 01 21:23:22 CST 2022, time=2022-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836264, encodeId=ad011836264d5, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Sun Aug 22 22:23:22 CST 2021, time=2021-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661642, encodeId=c46e16616422e, content=<a href='/topic/show?id=1b3c1315481' target=_blank style='color:#2F92EE;'>#nutrition#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13154, encryptionId=1b3c1315481, topicName=nutrition)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0d25331316, createdName=膀胱癌, createdTime=Mon May 09 20:23:22 CST 2022, time=2022-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1818115, encodeId=bdf71818115c4, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Tue Nov 02 18:23:22 CST 2021, time=2021-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1470469, encodeId=b7dc14e046928, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Sun Jun 20 01:23:22 CST 2021, time=2021-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048807, encodeId=d670104880ea1, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Fri Jun 18 13:23:22 CST 2021, time=2021-06-18, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=2118412, encodeId=2dec21184122e, content=<a href='/topic/show?id=b730105511d0' target=_blank style='color:#2F92EE;'>#低同型半胱氨酸血症#</a>可能会增加患<a href='/topic/show?id=18b3e120514' target=_blank style='color:#2F92EE;'>#痴呆#</a>症和<a href='/topic/show?id=3cbe9e7892e' target=_blank style='color:#2F92EE;'>#阿尔茨海默病#</a>的风险,这个如何解释?<a href='/topic/show?id=3522389386f' target=_blank style='color:#2F92EE;'>#同型半胱氨酸#</a>高了不好,低了也不好?, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=105511, encryptionId=b730105511d0, topicName=低同型半胱氨酸血症), TopicDto(id=71205, encryptionId=18b3e120514, topicName=痴呆), TopicDto(id=97789, encryptionId=3cbe9e7892e, topicName=阿尔茨海默病), TopicDto(id=38938, encryptionId=3522389386f, topicName=同型半胱氨酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Thu Mar 09 04:30:37 CST 2023, time=2023-03-09, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=1817092, encodeId=c441181e0927d, content=<a href='/topic/show?id=17b59e77626' target=_blank style='color:#2F92EE;'>#阿尔茨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97776, encryptionId=17b59e77626, topicName=阿尔茨)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Bnia2EtH2IvyBtniaWHPQOYAicsN3IAL1ZuPV7qyALcdCiawRJdEiafMxWTxzERQW7eeKg8HfCKCRK2CJicy073C4RJg/132, createdBy=464b2500186, createdName=ms1948154235210413, createdTime=Sat Jan 01 21:23:22 CST 2022, time=2022-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836264, encodeId=ad011836264d5, content=<a href='/topic/show?id=4613e1212fc' target=_blank style='color:#2F92EE;'>#痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71212, encryptionId=4613e1212fc, topicName=痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=726030, createdName=Boyinsh, createdTime=Sun Aug 22 22:23:22 CST 2021, time=2021-08-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1661642, encodeId=c46e16616422e, content=<a href='/topic/show?id=1b3c1315481' target=_blank style='color:#2F92EE;'>#nutrition#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13154, encryptionId=1b3c1315481, topicName=nutrition)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6f0d25331316, createdName=膀胱癌, createdTime=Mon May 09 20:23:22 CST 2022, time=2022-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1818115, encodeId=bdf71818115c4, content=<a href='/topic/show?id=4c9f9e777ac' target=_blank style='color:#2F92EE;'>#阿尔茨海#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97777, encryptionId=4c9f9e777ac, topicName=阿尔茨海)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Tue Nov 02 18:23:22 CST 2021, time=2021-11-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1470469, encodeId=b7dc14e046928, content=<a href='/topic/show?id=45a79e7788c' target=_blank style='color:#2F92EE;'>#阿尔茨海默#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97778, encryptionId=45a79e7788c, topicName=阿尔茨海默)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c5917090900, createdName=yhj-time, createdTime=Sun Jun 20 01:23:22 CST 2021, time=2021-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048807, encodeId=d670104880ea1, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Fri Jun 18 13:23:22 CST 2021, time=2021-06-18, status=1, ipAttribution=)]
    2021-06-18 junJUN

    老年人痴呆何药可用??

    0

相关资讯

Sci Trans Med:Tau抗体semorinemab I期临床安全

Semorinemab还显示了体内靶点参与的明确证据,在tau转基因小鼠、非人灵长类动物和人类中观察到全身tau浓度的增加。与健康对照组相比,AD参与者用药后观察到更高的全身tau浓度。

Nat Aging:阿尔兹海默症疫苗来了!2期临床试验有效诱导免疫应答

这是一项为期24个月的双盲、平行臂、随机的2期多中心安慰剂对照试验,其中AADvac1是一种活性肽疫苗,旨在针对AD的病理性tau蛋白(EudraCT 2015-000630-30)。

Neurology: 遗传性阿尔茨海默病,脑内微出血预示痴呆风险增加

遗传性阿尔茨海默病,脑内微出血预示痴呆风险增加

Nat Commun:耗竭B细胞可逆转阿尔茨海默病的进展

尽管表达了促进AD的转基因,但仅损失B细胞就足以减少Aβ斑块负担和疾病相关的小胶质细胞,此外,该疗法还分别逆转了行为和记忆障碍,并恢复了TGFβ+小胶质细胞。

Nat Commun:究竟是哪些基因变异导致我们更易得阿尔茨海默病?

研究人员首先通过合并所有可用的病例对照数据集和代理研究结果(发现人数=409,435,验证人数=58,190)进行了一项大型的遗传关联研究。