Eur Respir J:哮喘与COPD共存:危险因素、临床病史和肺功能轨迹

2021-04-30 MedSci原创 MedSci原创

与单纯COPD相比,哮喘和COPD之间的共存似乎起源于生命的早期。这些结果表明,预防这种严重的疾病(在老年人中很常见)应该从儿童期开始。

伴有哮喘的慢性阻塞性肺疾病(COPD)患者的疾病负担很重。

近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,研究人员使用欧洲共同体呼吸健康调查中前瞻性收集的数据,比较了成年早期至中年患有哮喘+COPD(n=179)、过去(n=263)或当前(n=808)仅有哮喘、仅COPD(n=111)或既无哮喘也无COPD(n=3477)患者。

研究人员在1991-1993年、1999-2002年和2010-2013年的3次临床评估中获得了受试者的访谈数据和支气管扩张剂前FEV1和FVC。根据固定的气流阻塞(支气管扩张剂后FEV1/FVC低于正常下限)、哮喘终生病史和累积接触烟草的情况,在2010-2013年年龄为40-68岁的受试者按照疾病状态进行分类。研究人员估计了既往的肺功能轨迹、临床特征和这些表型的危险因素。

哮喘+COPD患者报告的母亲吸烟(28.2%)和儿童期呼吸道感染(19.1%)的发生频率高于单纯COPD患者(分别为20.9和14.0%)。患有哮喘+COPD受试者在20岁时的肺功能损害可以追溯到成年时期,其中一半以上的儿童在儿童期就有哮喘发病。单纯COPD患者终生接触吸烟和职业吸入剂的次数最高,并且他们在成年后表现出肺功能下降加快。

由此可见,与单纯COPD相比,哮喘和COPD之间的共存似乎起源于生命的早期。这些结果表明,预防这种严重的疾病(在老年人中很常见)应该从儿童期开始

原始出处:

Alessandro Marcon,et al.The coexistence of asthma and COPD: risk factors, clinical history and lung function trajectories.Eur Respir J.2021.https://erj.ersjournals.com/content/early/2021/04/08/13993003.04656-2020

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    2021-11-20 moyanju2796

    学习了。

    0

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    2021-05-02 ms3000000892837217

    学习了

    0

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    2021-05-01 yangchou

    好文章,共享之。

    0

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