JAHA:银屑病对心肌梗死患者死亡率和结局的影响

2020-09-14 MedSci原创 MedSci原创

在所有MI病例中,只有0.3%的患者被诊断为银屑病,而患有银屑病的MI患者比没有银屑病的MI患者中位年龄要小5岁。银屑病似乎可以增加已知心血管危险因素的患病率。

银屑病是一种常见的慢性炎性细胞因子介导的皮肤病,被确定为心肌梗塞(MI)的独立危险因素。但是,有关银屑病对心梗患者死亡率和其他院内不良事件影响的数据较少且不一致。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员使用2005年至2016年期间德国住院病人样本进行统计分析。住院的MI患者根据有无银屑病进行分层,并调查银屑病对院内事件的影响。

总体而言,在德国(2005-2016年)有3307703名MI患者(37.6%的女性,超过70岁的患者占56.8%)接受了治疗;其中9028名(0.3%)患者被诊断为银屑病。银屑病的MI患者明显年轻(68.0[58.0-76.0] vs. 73.0 [62.0-81.0]岁;P<0.001),院内病死率显著降低(7.1% vs. 12.4%;P<0.001) ,并在年龄、性别和合并症校正后的回归分析得到确认(比值比为0.68;95%CI为0.63-0.74;P<0.001)。他们存在心血管危险因素的频率更高,例如动脉高血压(58.9% vs. 55.0%;P<0.001)、高脂血症(44.4% vs. 38.6%;P<0.001)、吸烟(14.3% vs. 7.4%;P<0.001)、糖尿病(34.8% vs. 30.4%;P<0.001)或肥胖(17.9% vs. 9.3%;P<0.001)。尽管两组的经皮冠状动脉介入治疗的几率(41.4 vs. 42.0%;P=0.223)相当,但银屑病合并MI的患者更常接受冠状动脉搭桥术(7.7% vs. 4.7%;P<0.001)。

由此可见,在所有MI病例中,只有0.3%的患者被诊断为银屑病,而患有银屑病的MI患者比没有银屑病的MI患者中位年龄要小5岁。银屑病似乎可以增加已知心血管危险因素的患病率。该研究的数据还表明,伴有银屑病的心肌梗死患者院内死亡率较低,这可能是由于年龄较小所致。

原始出处:

Susanne Karbach.et al.Impact of Psoriasis on Mortality Rate and Outcome in Myocardial Infarction.J AM HEART ASSOC.2020.https://www.ahajournals.org/doi/10.1161/JAHA.120.016956

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    2020-09-16 zhaohui6731
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    2020-09-15 124ce738m58暂无昵称

    好东西!!!

    0

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    2020-09-15 yangchou

    好文章,学习了

    0

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    2020-09-14 辣妈

    学习了

    0

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    2020-09-14 lovetcm

    #银屑病##心肌梗死#患者院内死亡率较低,这可能是由于年龄较小所致。

    0

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