Mucosal Immunology新发现:膳食纤维可能有助于预防皮肤过敏

2022-06-24 好医生 好医生

虽然肠道微生物组塑造了免疫系统已得到公认,但它对皮肤的影响却没有得到充分探讨。

莫纳什大学的一项新研究发现,肠道中的膳食纤维的微生物发酵可以保护过敏性皮肤病。研究结果发表在《Mucosal Immunology 》上。

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在该研究中,研究人员把小鼠分为两组,给它们喂食高浓度的可发酵纤维或纯化的短链脂肪酸(SCFA)。

两组的结果都是皮肤屏障得到了强化,以抵御过敏原(本研究使用的是屋尘螨过敏原)。这些过敏原通常会穿透皮肤屏障,激活免疫系统并在这些模型中启动过敏反应。 

研究人员研究了膳食纤维和SCFA的作用方式:他们用同位素标记了丁酸盐,并在小鼠体内对其进行了追踪——它只花了几分钟就到达了皮肤,在那里它增强了角质细胞的代谢,促使它们成熟并产生健康皮肤屏障所需的关键结构成分。

研究人员表示,本研究的主要结论是:食用膳食纤维对促进皮肤屏障功能从而限制过敏原的进入和随后的致敏和疾病至关重要

研究的通讯作者、莫纳什大学中央临床学院免疫学系的Benjamin J. Marslan教授说:“事实证明,免疫系统是这种皮肤屏障功能的次要组成部分。积极改善皮肤屏障可能对导致过敏的环境暴露产生保护作用,甚至可能对其他皮肤疾病产生保护作用,这些疾病是由受损或薄弱的皮肤屏障支撑的。”

“短链脂肪酸可以局部给药且耐受性良好,这一事实为制定预防策略或改变疾病的干预措施提供了可能性——这代表了我们研究的最重要的转化潜力。”Marsland教授说,“要探索的一种可能性是,这是否可以帮助那些有可能发展成皮肤过敏的儿童,这些皮肤过敏会连带导致食物过敏和哮喘,即所谓的‘特应性进展’。”

原始出处

Benjamin J. Marsland et al., Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation., Mucosal Immunology (2022). DOI: 10.1038/s41385-022-00524-9

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    2022-06-26 bioon3
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    2022-06-26 zhaojie88
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    2022-06-24 124b0d0cm23暂无昵称

    学习了

    0

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