Stroke:老年人房颤与脑小血管疾病相关

2021-06-17 MedSci原创 MedSci原创

房颤与老年人白质病变加速进展和脑室扩大相关。

脑小血管疾病作为房颤和痴呆之间联系的潜在机制,目前仍未明确。近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,在这项队列研究中,研究人员试图评估老年人房颤和脑小血管疾病标志物之间的相关性。

该研究中336名(年龄≥60岁,平均为70.2岁;60.2%为女性)无痴呆、残疾和脑梗死的参与者的数据来自于斯德哥尔摩地区以人群为基础的瑞典全国老龄化和护理研究。参与者在基线(2001-2004年)和随访(2004-2007年和2007-2010年)期间进行了脑结构磁共振成像检查。

脑小血管疾病的磁共振成像标记物包括血管周围间隙、腔隙、白质高信号、侧脑室和全脑组织的体积。研究人员在基线和随访期间通过临床检查、心电图和医疗记录对房颤进行了评估。数据采用线性混合效应模型进行分析。

基线时,18人(5.4%)被确定为房颤,17人(5.6%)在6年的随访中发展为房颤。多变量调整后,房颤与白质高信号体积(β系数=0.45 [95%CI为0.04-0.86])和侧脑室体积(0.58[0.13-1.02])的快速增大显著相关。房颤与血管周围间隙数(β系数=0.53 [95%CI为-0.27~1.34])或腔隙数(-0.01[-0.07~0.05])的年度变化无显著相关性。

由此可见,独立于脑梗死,房颤与老年人白质病变加速进展和脑室扩大相关。

原始出处:

Mozhu Ding.et al.Cerebral Small Vessel Disease Associated With Atrial Fibrillation Among Older Adults: A Population-Based Study.stroke.2021.https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.031573

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    2021-06-18 Linxuezhang

    学到了

    0

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    2021-06-18 12589280m60暂无昵称

    学习了

    0

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    2021-06-18 心介

    房颤,临床上碰到很多哦

    0

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    2021-06-17 wxl882001

    了解

    0

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