J INTERN MED:COVID-19患者动脉僵硬度及其与临床结局的潜在关联

2021-03-06 MedSci原创 MedSci原创

COVID-19似乎与PWV升高有关,表明这类患者动脉僵硬度有所增加。较高的PWV可能与住院时间延长和死亡率增加有关。

2019新冠肺炎COVID-19)会扰乱血管内皮功能,但是COVID-19是否还会影响动脉僵硬度尚未明确。

近日,内科学领域权威杂志Journal of Internal Medicine上发表一篇研究文章,这项病例对照研究比较了伴有和伴有COVID-19的急性病患者的肱-踝动脉脉搏波传导速度(baPWV))和颈-股动脉脉搏波传导速度(cfPWV)。

研究人员将22名COVID-19患者(50%为女性患者,平均年龄为77 [67-84]岁)与22名年龄和性别匹配的对照者进行了比较。

在COVID-19患者中,baPWV(19.9 [18.4-21.0] vs. 16.0 [14.2-20.4],p=0.02)和cfPWV(14.3 [13.4-16.0] vs. 11.0 [9.5-14.6],p=0.01)高于对照者。在多元回归分析中,COVID-19独立地与较高的cfPWV(β=3.164,p=0.004)和baPWV(β=3.532,p=0.003)相关。COVID-19非幸存者的PWV值较高。在COVID-19幸存者中,PWV与住院时间长短有关。

由此可见,COVID-19似乎与PWV升高有关,表明这类患者动脉僵硬度有所增加。较高的PWV可能与住院时间延长和死亡率增加有关

原始出处:

Bertil Lindahl.et al.Poor long‐term prognosis in patients admitted with strong suspicion of acute myocardial infarction but discharged with another diagnosis.J INTERN MED.2021.https://onlinelibrary.wiley.com/doi/10.1111/joim.13272

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