Clinical Nutrition: 妊娠前三个月孕期维生素D状况与妊娠糖尿病的关系

2021-02-23 MedSci原创 MedSci原创

妊娠糖尿病(GDM)是指在怀孕期间发作的对葡萄糖不耐受的情况,其严重程度可轻可重。

      妊娠糖尿病(GDM)是指在怀孕期间发作的对葡萄糖不耐受的情况,其严重程度可轻可重。GDM的最常见风险因素是高龄产妇,有过GDM病史或2型糖尿病家族史,肥胖或超重等。除此之外,GDM还与不良妊娠结局,胎儿和新生儿并发症以及肥胖,代谢风险增加有关。目前,人们对维生素D及其在代谢性疾病发展中的潜在作用越来越感兴趣,这项研究的目的是根据孕早期的维生素D状况评估GDM的风险。

 

 

      这项研究是一项病例对照研究,将检测了25-羟基维生素D水平(25OHD)的孕妇纳入本项研究。队列中包含了250例患有GDM的妇女(病例),并按照年龄,身高体重等因素匹配了941例没有GDM的妇女,所有患者的怀孕胎次,年龄,怀孕前的体重指数,受孕的季节均没有显著差异。

 

 

      研究结果显示25OHD水平<20 ng / mL的患者,GDM的风险明显更高(OR = 1.42,95%CI 1∙06–1∙91;p = 0.021)。对25OHD水平的研究以5分位数的间隔进行更精确分析后显示与GDM风险的可变关系,结果更加有趣:非常低的25OHD水平患GDM的风险很低,中等水平患GDM的风险有所增加增加,正常水平25OHD患GDM的风险也很低低,较高25OHD水平患者患GDM的风险又有所增加。

 

 

      因此,通过本项研究证实,妊娠前三个月GDM与25OHD水平之间似乎没有线性关系,因为随着25OHD浓度增加,GDM风险不会持续降低,但是25OHD水平的确是GDM发病的危险因素。

 

 

 

原始出处:

Eleonora Salakos. Et al. Relationship between vitamin D status in the first trimester of pregnancy and gestational diabetes mellitus - A nested case–control study.Clinical Nutrition. 2021.

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    2021-08-10 宋旭萍1253494900

    学习了。

    0

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    2021-04-21 Ms🧐🧐🧐🧐🧐🧐

    谨受教

    0

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    2021-02-25 zll0628
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    2021-02-23 misszhang

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Clinical Nutrition: 妊娠前三个月维生素D状况与妊娠糖尿病之间的关系

妊娠期糖尿病(GDM)是怀孕期间最常见的并发症之一。从长远来看,它与许多不良妊娠,胎儿和新生儿结局以及母亲和儿童的风险增加有关。人们对维生素D及其在代谢性疾病发展中的潜在作用越来越感兴趣。

Dig Dis Sci:严重缺乏维生素D对炎症性肠病临床病程的影响

克罗恩病(CD)和溃疡性结肠炎(UC)是炎性肠病(IBD)的两种形式,是特发性的慢性复发性疾病,随着IBD在西方和东方国家的普及率不断提高。

JAMA Netw Open:孕期补充高剂量维生素D并不能改善后代的神经发育

维生素D缺乏症是缺乏维生素D所表现出来的一系列病症,可能是由于摄入的维生素D不足,并且没有接受足够多的阳光照射导致的,也有可能是体内发生的紊乱导致维生素D的吸收受限。

JAMA:单高剂量维生素D3不能缓解中度或重度新型冠状肺炎

通过补充维生素D治疗新冠肺炎并不靠谱

Complement Ther Clin Pract:子宫肌瘤患者是不是要多吃维生素D?

子宫肌瘤是女性生殖系统的常见肿瘤。有症状的子宫肌瘤需要根据症状的严重程度进行手术或其他治疗。最近,维生素D已被确定为一种潜在的抗肿瘤化合物,可抑制子宫肌瘤细胞,减少肌瘤病变。 最近的证据表明,维生素D

Nat Commun:孟德尔随机化分析评估维生素D与癌症易感性的关联性

维生素D是一种必需的脂溶性维生素,主要是由皮肤暴露于紫外线辐射所产生的。