Pharm Biol:桃红四物汤通过改善BDNF-CREB-精氨酸酶I轴紊乱改善模型大鼠抑郁症状

2022-09-16 紫菀款冬 MedSci原创

探索中药复方桃红四物汤(TSD)对抑郁障碍(DD)动物模型的有效治疗靶点。

背景:中药复方桃红四物汤(TSD)的传统用途是用于治疗缺血性中风,既往研究发现TSD中的草药含有的生物活性化合物,如阿魏酸和白花苷,可改善炎症和抑郁症状,表明TSD具有治疗抑郁障碍(DD)的潜力。然而目前尚无研究集中于TSD的抗抑郁功能。

目的:探讨TSD对DD动物模型的有效靶点。

方法:Sprague-Dawley(SD)大鼠通过在35天内诱导慢性不可预测轻度应激(CUMS)建立模型,并用三种剂量的TSD(2.5、5和10 g/kg )或氟西汀(10  mg/kg)灌胃治疗14天。

进行体重测量和行为测试,以观察TSD对CUMS动物的影响。气相色谱-质谱联用(GC-MS)代谢组学分析用于揭示与TSD疗效相关的代谢特征。分析与特征代谢物相关的蛋白质水平。

结果:通过TSD治疗,行为测试中减少的不动持续时间和交叉平方分别平均提高了48.6%和32.9%(ED50=3.2 g/kg)。TSD的抗抑郁作用与13种代谢物的减少以及血清中鸟氨酸和尿素的恢复有关。

TSD(5  g/kg)使CUMS大鼠血清中的5-羟色胺升高54.1 mg/dL,但精氨酸酶I(Arg I)降低47.8 mg/dL。在CUMS大鼠中,脑源性神经营养因子(BDNF)-cAMP反应元件结合蛋白(CREB)轴上调节Arg I抑制的蛋白受到抑制,但通过TSD干预得以逆转。

结论:TSD改善CUMS大鼠的抑郁样症状。进一步的研究将集中于TSD中所含有效化合物的抗抑郁作用。

 

文献来源:

Zhang X, Li Z, Shen C, et al. Tao-Hong-Si-Wu decoction improves depressive symptoms in model rats via amelioration of BDNF-CREB-arginase I axis disorders. Pharm Biol. 2022;60(1):1739-1750. doi:10.1080/13880209.2022.2116460

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    2022-12-16 jj000001
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    2023-08-02 sunylz
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    2022-09-17 apoenzyme
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    2022-09-17 HinsMax
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    2022-09-17 小小医者

    #桃红四物汤#通过改善BDNF-CREB-精氨酸酶I轴紊乱改善模型大鼠#抑郁#症状,也是乱做研究了!#中医#是不是异化了?

    0

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