J Bone Oncol:诊断时有骨转移的小细胞肺癌患者的临床结局

2020-04-23 MedSci原创 MedSci原创

小细胞肺癌(SCLC)患者初诊时有骨转移的小细胞肺癌(SCLC)患者的特点和预后因素几乎没有报道。本研究旨在分析这些患者的预后因素,建立生存评分系统,为临床治疗决策提供依据。

小细胞肺癌(SCLC)患者初诊时有骨转移的小细胞肺癌(SCLC)患者的特点和预后因素几乎没有报道。本研究旨在分析这些患者的预后因素,建立生存评分系统,为临床治疗决策提供依据。

 

回顾性分析2010年5月至2015年5月在我院就诊的102例SCLC骨转移患者的诊断。对数秩检验和多因素Cox回归分析用于评估生存的潜在临床预测指标。基于重要的独立预后因素的危险比,开发了评分系统。

 

结果显示,骨转移最常见的部位是脊柱(64.7%),并且26位患者(25.6%)发生了单一骨转移。中位生存期为10.4个月,两年生存率为10.3%。年龄,骨转移的数量和骨外远处转移的发生是整体生存的重要独立预后因素。根据评分,将患者分为三组。三组患者的中位生存时间分别为6.4个月,8.5个月和12.4个月,两年生存率分别为0%,2.9%和19.3%(p = 0.000)。26位患者(25.5%)发生了骨骼相关事件(SRE),最常见的SRE是放射至骨骼(22.5%)和脊髓受压(11.8%)。

 

综上所述,该研究包括诊断时患有骨转移的SCLC患者的初步临床数据,需要进行更多研究。

 

原始出处:

 

Linlin GongLiming Xu, et al., Clinical outcome for small cell lung cancer patients with bone metastases at the time of diagnosis. J Bone Oncol. 2019 Dec; 19: 100265.

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    2020-07-02 minlingfeng
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    2020-06-04 apoenzyme
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    2020-04-24 148a6826m20(暂无昵称)

    系统,为临床治疗决策提供依据。

    0

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    2020-04-23 anti-cancer

    谢谢梅斯分享这么多精彩信息

    0

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由此可见,骨转移在转移性MTC中很常见,并且最常见的是溶骨性转移且预后不良。大多数SRE发生在溶骨性转移中,可以通过抗吸收治疗加以预防。

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研究认为,RANKL抑制剂Denosumab并未改善高危早期乳腺癌患者的疾病相关预后

恶性肿瘤骨转移双膦酸盐类药物相关性颌骨坏死六例临床分析

双膦酸盐类药物(BP)目前被广泛用于治疗晚期恶性肿瘤骨转移及骨并发症,但这类药物在治疗过程中的不良反应也逐步被报道。2003年,Marx首次报道了长期使用唑来膦酸的患者出现下颌骨坏死的现象,引起口腔医生的重视。2007年,美国口腔颌面外科医师协会(AAOMS)确立了双膦酸盐相关性颌骨坏死(BRONJ)的诊断标准。

肝细胞癌骶骨转移1例

肝癌位居世界常见恶性肿瘤第6位,其死亡率居第3位,绝大多数为肝细胞癌(HCC)。近年来,肝癌诊断和治疗策略有所改善,患者生存时间得到延长,但5年生存率仍较低(16%),若发生肝外转移,生存率仅为4%。

Biochem Pharmacol:PAK1抑制剂IPA-3能够减轻转移前列腺癌诱导的骨重建

转移前列腺癌(PCa)具有高度的致死性和低的5年生存率,主要是由于缺乏有效的治疗措施。骨是人类PCa转移的主要位点,对骨转移PCa可靠治疗选择开发将对减少这些患者的死亡率产生重大影响。

以骨转移灶症状为首发表现的恶性黑色素瘤1例

黑色素瘤易发生骨转移,脊柱是其好发的转移部位。但临床以骨转移灶症状为首发症状的黑色素瘤罕见。广州中医药大学第一附属医院脊柱骨科收治以骨转移灶症状为首发症状的恶性黑色素瘤1例,报道如下。