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ARCH PATHOL LAB MED：三角样蛋白3在小细胞肺癌中的流行率及DLL3 (SP347)特征

2019-12-02 MedSci MedSci原创

三角样蛋白小细胞肺癌
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既往研究表明，类三角蛋白3 (deltalike protein 3, DLL3)是一种参与Notch通路的蛋白。本研究的目的是介绍VENTANA DLL3 (SP347)法检测小细胞肺癌中DLL3的患病率及染色特征。此外，本研究还对该方法与其他肿瘤和非肿瘤组织的免疫反应性进行了概述。

既往研究表明，类三角蛋白3 (deltalike protein 3, DLL3)是一种参与Notch通路的蛋白。本研究的目的是介绍VENTANA DLL3 (SP347)法检测小细胞肺癌中DLL3的患病率及染色特征。此外，本研究还对该方法与其他肿瘤和非肿瘤组织的免疫反应性进行了概述。

研究中，研究人员涉及并获得了小细胞肺癌的单个福尔马林固定、石蜡包埋标本和包含肿瘤和非肿瘤组织的组织芯片，切片用DLL3 (SP347)染色。检查载玻片以确定患病率、染色特征和免疫反应性。

研究显示，1362例小细胞肺癌标本中有1040例(76.4%)出现胞质和/或膜质染色。并注意到强度变化的同质和/或异质和部分和/或圆周的颗粒染色。在其他肿瘤和非肿瘤组织中也观察到免疫反应性。

本研究结果提供了DLL3染色特征的概况，可用于测定小细胞肺癌中DLL3的表达水平。

原始出处：

Richard S. P. Huang, MD; Burton F. Holmes, PhD;Delta-like Protein 3 Prevalence in Small Cell Lung Cancer and DLL3 (SP347) Assay Characteristics

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    2020-04-08 lixiaol

    #流行率#

    0

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    2020-05-11 yb6560

    #Pathol#

    0

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    2020-07-11 1179102698_36768926

    #三角样蛋白#

    0

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    2019-12-04 ms3994565386320060

    #Med#

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