JAMA Surg:二甲双胍可降低糖尿病患者术后不良预后风险

2020-04-13 MedSci原创 MedSci原创

II型糖尿病患者在术前接受二甲双胍治疗可降低术后死亡及再入院风险

患有共病人群,在重大手术干预的压力下,术后死亡率和再入院率增加。近日研究人员评估了糖尿病患者术前二甲双胍处方与术后死亡率和再入院率之间的关系。

研究在宾夕法尼亚州开展,2010-16年间接受大手术并入院的糖尿病患者参与,随访至2018年底。在术前180天接受二甲双胍治疗的患者定义为术前二甲双胍处方暴露人群。研究的主要终点为有或无二甲双胍处方的患者术后全因死亡率、出院后90天内再次入院、术前中性粒细胞与白细胞比值测定的炎症差异。

10088名接受主要外科手术的糖尿病患者中,5962人(59%)有术前二甲双胍暴露,参与者年龄为67.7岁,2866名(53%)为女性。在倾向评分匹配队列中,术前二甲双胍暴露降低患者90天死亡率(校正HR:0.72;ARR:1.28%)和再入院风险相关。与未服用二甲双胍的患者相比,服用二甲双胍的患者术前炎症症状较轻(平均中性粒细胞与白细胞比率为4.5 vs 5.0)。

研究发现,II型糖尿病患者在术前接受二甲双胍治疗可降低术后死亡及再入院风险。

原始出处:

Katherine M. Reitz et al. Association Between Preoperative Metformin Exposure and Postoperative Outcomes in Adults With Type 2 Diabetes.JAMA Surg. April 8, 2020.

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    2020-10-12 ms2000000624889280

    多谢

    0

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    2020-04-21 期刊杂志小干gqVSzyq

    辛苦分享

    0

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    2020-04-13 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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    2020-04-13 misszhang

    二甲双胍,神药!

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    2020-04-13 misszhang

    谢谢MedSci提供最新的资讯

    0

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