Dig Dis Sci: 炎症性肠病中存在肠易激综合征症状的患者易发生焦虑和抑郁

2019-07-06 不详 MedSci原创

炎症性肠病(IBD)和肠易激综合征(IBS)具有重叠的临床症状。静息IBD中IBS的流行病学研究很少。因此,本项研究的目的是根据HBI指数确定患有IBS的IBD患者处于深度缓解期的百分比,其持续的IBS样症状是否会导致它们被归类为患有疾病活动期。

背景
炎症性肠病(IBD)和肠易激综合征(IBS)具有重叠的临床症状。静息IBD中IBS的流行病学研究很少。因此,本项研究的目的是根据HBI指数确定患有IBS的IBD患者处于深度缓解期的百分比,其持续的IBS样症状是否会导致它们被归类为患有疾病活动期。

方法
这是一项前瞻性研究。总共有96名IBD患者完成了结肠镜检查和组织学检查,并同意并完成了罗马III标准的IBS调查,以及填写了医院焦虑和抑郁量表(HADS)。

结果
分别有36%(28/77)和37%(7/19)的CD和UC患者符合IBS的诊断标准。患有IBS的IBD患者有显着更高的HBI / UCDAI分数(p= 0.005)和较低的炎症性肠病问卷(SIBDQ)得分(p ≤0.0001)。当完全符合罗马III标准的IBS时,29%的深度缓解患者被HBI / UCDAI错误归类为疾病活动期。精神病诊断(OR 3.53 95%CI 1.2-10.2)和早期IBD发病(OR 1.056 95%CI 1.015-1.096)与IBD / IBS +相关。符合IBS标准的患者具有较高的医院焦虑和抑郁量表(HADS)评分。

结论
患有IBS的IBD患者有着更为严重的临床症状,并且他们有着更高的焦虑和抑郁发作风险。

抑郁相关筛查量表:


与炎症性肠病相关量表:


原始出处:

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    2019-07-07 130****4638

    学习了,谢谢分享。

    0

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    2019-07-06 百草

    666

    0

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    2019-07-06 明天jing

    焦虑是当年年轻人的共同问题,需要认真对待。

    0

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