肿瘤科

订阅

MedSci主页 / 所有栏目 / 肿瘤科

Blood：造血细胞移植治疗Wiskott-Aldrich综合征的预后

2020-04-19 QQY MedSci原创

血小板减少造血细胞移植Wiskott-Aldrich综合征
关注

年龄与总存活率(OS)有显著的相关性，HCT时年龄不足5岁的患者的OS更好。 供体髓细胞移植<50%与HCT后的血小板恢复不良有关。

奥尔德里奇(Wiskott-Aldrich)综合征(WAS)是一种X染色体连锁病，是由WAS基因突变引起的，可导致血小板减少、湿疹、复发性感染、自身免疫性疾病和恶性肿瘤。造血细胞移植(HCT)是主要的治疗方法，其目的是纠正潜在的免疫缺陷和血小板减少。

随着时间的推移，HCT的预后有所改善，特别是对于有与HLA匹配的兄弟姐妹和无相关的捐赠者的患者。本研究报道了2005年-2015年在29个原发性免疫缺陷治疗联合中心采用HCT治疗的129位WAS患者的预后。

HCT时的中位年龄是1.2岁。大部分患者（65%）进行了骨髓清除白消安为基础的调理。中位随访4.5年，5年总体存活率（OS）达91%。与满5岁时进行HCT的患者相比，不满5岁时进行HCT的5年OS明显更好（94% vs 66%）。

即使在脐带血受体中，无论供体类型如何，OS都是非常好（90%）。调节强度不影响OS，但与HCT后供体T细胞和髓细胞移植相关。特别是接受氟达拉滨/美法仑为基础的低强度治疗方案的患者更有可能在HCT后早期出现供体骨髓嵌合<50%。

此外，与低比例(5%-49%)髓细胞移植的受体相比，进行全(>95%)髓细胞移植的受体的血小板计数更高。

总而言之，自2005年以来，WAS的HCT预后较既往报道的有所改善。高比例的供体髓细胞移植对血小板重建至关重要。

原始出处：

Lauri Burroughs， et al. Excellent Outcomes Following Hematopoietic Cell Transplantation for Wiskott-Aldrich Syndrome： A PIDTC Report. Blood. April 8， 2020.

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (8)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1668903, encodeId=5d6116689031c, content=<a href='/topic/show?id=227518e107b' target=_blank style='color:#2F92EE;'>#Wiskott-Aldrich综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18710, encryptionId=227518e107b, topicName=Wiskott-Aldrich综合征)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ffcc26471069, createdName=guojianrong, createdTime=Thu Jul 02 12:03:30 CST 2020, time=2020-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1658930, encodeId=62d516589309c, content=<a href='/topic/show?id=c40ce798412' target=_blank style='color:#2F92EE;'>#细胞移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77984, encryptionId=c40ce798412, topicName=细胞移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4724938298, createdName=limedical1982, createdTime=Mon Mar 22 04:03:30 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1681870, encodeId=5a9b16818e01c, content=<a href='/topic/show?id=2fb489882cb' target=_blank style='color:#2F92EE;'>#血细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89882, encryptionId=2fb489882cb, topicName=血细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a79127868468, createdName=ailian1211, createdTime=Sun May 10 15:03:30 CST 2020, time=2020-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316378, encodeId=ecb813163e8d0, content=<a href='/topic/show?id=f3789349c3' target=_blank style='color:#2F92EE;'>#ICH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9349, encryptionId=f3789349c3, topicName=ICH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431815, encodeId=321b143181584, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469419, encodeId=2430146941985, content=<a href='/topic/show?id=9d6522e613' target=_blank style='color:#2F92EE;'>#ALD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2276, encryptionId=9d6522e613, topicName=ALD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64f67025397, createdName=zhangjingnwpu, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494723, encodeId=04ca1494e234f, content=<a href='/topic/show?id=084d9499599' target=_blank style='color:#2F92EE;'>#造血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94995, encryptionId=084d9499599, topicName=造血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=caed9138962, createdName=俅侠, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621139, encodeId=99f116211394c, content=<a href='/topic/show?id=6ba69501350' target=_blank style='color:#2F92EE;'>#造血细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95013, encryptionId=6ba69501350, topicName=造血细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d6e720195877, createdName=lq1774, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=)]
    2020-07-02 guojianrong

    #Wiskott-Aldrich综合征#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1668903, encodeId=5d6116689031c, content=<a href='/topic/show?id=227518e107b' target=_blank style='color:#2F92EE;'>#Wiskott-Aldrich综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18710, encryptionId=227518e107b, topicName=Wiskott-Aldrich综合征)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ffcc26471069, createdName=guojianrong, createdTime=Thu Jul 02 12:03:30 CST 2020, time=2020-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1658930, encodeId=62d516589309c, content=<a href='/topic/show?id=c40ce798412' target=_blank style='color:#2F92EE;'>#细胞移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77984, encryptionId=c40ce798412, topicName=细胞移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4724938298, createdName=limedical1982, createdTime=Mon Mar 22 04:03:30 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1681870, encodeId=5a9b16818e01c, content=<a href='/topic/show?id=2fb489882cb' target=_blank style='color:#2F92EE;'>#血细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89882, encryptionId=2fb489882cb, topicName=血细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a79127868468, createdName=ailian1211, createdTime=Sun May 10 15:03:30 CST 2020, time=2020-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316378, encodeId=ecb813163e8d0, content=<a href='/topic/show?id=f3789349c3' target=_blank style='color:#2F92EE;'>#ICH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9349, encryptionId=f3789349c3, topicName=ICH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431815, encodeId=321b143181584, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469419, encodeId=2430146941985, content=<a href='/topic/show?id=9d6522e613' target=_blank style='color:#2F92EE;'>#ALD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2276, encryptionId=9d6522e613, topicName=ALD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64f67025397, createdName=zhangjingnwpu, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494723, encodeId=04ca1494e234f, content=<a href='/topic/show?id=084d9499599' target=_blank style='color:#2F92EE;'>#造血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94995, encryptionId=084d9499599, topicName=造血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=caed9138962, createdName=俅侠, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621139, encodeId=99f116211394c, content=<a href='/topic/show?id=6ba69501350' target=_blank style='color:#2F92EE;'>#造血细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95013, encryptionId=6ba69501350, topicName=造血细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d6e720195877, createdName=lq1774, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=)]
    2021-03-22 limedical1982

    #细胞移植#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1668903, encodeId=5d6116689031c, content=<a href='/topic/show?id=227518e107b' target=_blank style='color:#2F92EE;'>#Wiskott-Aldrich综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18710, encryptionId=227518e107b, topicName=Wiskott-Aldrich综合征)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ffcc26471069, createdName=guojianrong, createdTime=Thu Jul 02 12:03:30 CST 2020, time=2020-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1658930, encodeId=62d516589309c, content=<a href='/topic/show?id=c40ce798412' target=_blank style='color:#2F92EE;'>#细胞移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77984, encryptionId=c40ce798412, topicName=细胞移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4724938298, createdName=limedical1982, createdTime=Mon Mar 22 04:03:30 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1681870, encodeId=5a9b16818e01c, content=<a href='/topic/show?id=2fb489882cb' target=_blank style='color:#2F92EE;'>#血细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89882, encryptionId=2fb489882cb, topicName=血细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a79127868468, createdName=ailian1211, createdTime=Sun May 10 15:03:30 CST 2020, time=2020-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316378, encodeId=ecb813163e8d0, content=<a href='/topic/show?id=f3789349c3' target=_blank style='color:#2F92EE;'>#ICH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9349, encryptionId=f3789349c3, topicName=ICH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431815, encodeId=321b143181584, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469419, encodeId=2430146941985, content=<a href='/topic/show?id=9d6522e613' target=_blank style='color:#2F92EE;'>#ALD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2276, encryptionId=9d6522e613, topicName=ALD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64f67025397, createdName=zhangjingnwpu, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494723, encodeId=04ca1494e234f, content=<a href='/topic/show?id=084d9499599' target=_blank style='color:#2F92EE;'>#造血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94995, encryptionId=084d9499599, topicName=造血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=caed9138962, createdName=俅侠, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621139, encodeId=99f116211394c, content=<a href='/topic/show?id=6ba69501350' target=_blank style='color:#2F92EE;'>#造血细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95013, encryptionId=6ba69501350, topicName=造血细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d6e720195877, createdName=lq1774, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=)]
    2020-05-10 ailian1211

    #血细胞#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1668903, encodeId=5d6116689031c, content=<a href='/topic/show?id=227518e107b' target=_blank style='color:#2F92EE;'>#Wiskott-Aldrich综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18710, encryptionId=227518e107b, topicName=Wiskott-Aldrich综合征)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ffcc26471069, createdName=guojianrong, createdTime=Thu Jul 02 12:03:30 CST 2020, time=2020-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1658930, encodeId=62d516589309c, content=<a href='/topic/show?id=c40ce798412' target=_blank style='color:#2F92EE;'>#细胞移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77984, encryptionId=c40ce798412, topicName=细胞移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4724938298, createdName=limedical1982, createdTime=Mon Mar 22 04:03:30 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1681870, encodeId=5a9b16818e01c, content=<a href='/topic/show?id=2fb489882cb' target=_blank style='color:#2F92EE;'>#血细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89882, encryptionId=2fb489882cb, topicName=血细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a79127868468, createdName=ailian1211, createdTime=Sun May 10 15:03:30 CST 2020, time=2020-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316378, encodeId=ecb813163e8d0, content=<a href='/topic/show?id=f3789349c3' target=_blank style='color:#2F92EE;'>#ICH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9349, encryptionId=f3789349c3, topicName=ICH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431815, encodeId=321b143181584, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469419, encodeId=2430146941985, content=<a href='/topic/show?id=9d6522e613' target=_blank style='color:#2F92EE;'>#ALD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2276, encryptionId=9d6522e613, topicName=ALD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64f67025397, createdName=zhangjingnwpu, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494723, encodeId=04ca1494e234f, content=<a href='/topic/show?id=084d9499599' target=_blank style='color:#2F92EE;'>#造血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94995, encryptionId=084d9499599, topicName=造血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=caed9138962, createdName=俅侠, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621139, encodeId=99f116211394c, content=<a href='/topic/show?id=6ba69501350' target=_blank style='color:#2F92EE;'>#造血细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95013, encryptionId=6ba69501350, topicName=造血细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d6e720195877, createdName=lq1774, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=)]
    2020-04-20 diushouji

    #ICH#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1668903, encodeId=5d6116689031c, content=<a href='/topic/show?id=227518e107b' target=_blank style='color:#2F92EE;'>#Wiskott-Aldrich综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18710, encryptionId=227518e107b, topicName=Wiskott-Aldrich综合征)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ffcc26471069, createdName=guojianrong, createdTime=Thu Jul 02 12:03:30 CST 2020, time=2020-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1658930, encodeId=62d516589309c, content=<a href='/topic/show?id=c40ce798412' target=_blank style='color:#2F92EE;'>#细胞移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77984, encryptionId=c40ce798412, topicName=细胞移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4724938298, createdName=limedical1982, createdTime=Mon Mar 22 04:03:30 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1681870, encodeId=5a9b16818e01c, content=<a href='/topic/show?id=2fb489882cb' target=_blank style='color:#2F92EE;'>#血细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89882, encryptionId=2fb489882cb, topicName=血细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a79127868468, createdName=ailian1211, createdTime=Sun May 10 15:03:30 CST 2020, time=2020-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316378, encodeId=ecb813163e8d0, content=<a href='/topic/show?id=f3789349c3' target=_blank style='color:#2F92EE;'>#ICH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9349, encryptionId=f3789349c3, topicName=ICH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431815, encodeId=321b143181584, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469419, encodeId=2430146941985, content=<a href='/topic/show?id=9d6522e613' target=_blank style='color:#2F92EE;'>#ALD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2276, encryptionId=9d6522e613, topicName=ALD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64f67025397, createdName=zhangjingnwpu, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494723, encodeId=04ca1494e234f, content=<a href='/topic/show?id=084d9499599' target=_blank style='color:#2F92EE;'>#造血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94995, encryptionId=084d9499599, topicName=造血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=caed9138962, createdName=俅侠, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621139, encodeId=99f116211394c, content=<a href='/topic/show?id=6ba69501350' target=_blank style='color:#2F92EE;'>#造血细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95013, encryptionId=6ba69501350, topicName=造血细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d6e720195877, createdName=lq1774, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=)]
    2020-04-20 zhouqu_8

    #综合征#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1668903, encodeId=5d6116689031c, content=<a href='/topic/show?id=227518e107b' target=_blank style='color:#2F92EE;'>#Wiskott-Aldrich综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18710, encryptionId=227518e107b, topicName=Wiskott-Aldrich综合征)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ffcc26471069, createdName=guojianrong, createdTime=Thu Jul 02 12:03:30 CST 2020, time=2020-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1658930, encodeId=62d516589309c, content=<a href='/topic/show?id=c40ce798412' target=_blank style='color:#2F92EE;'>#细胞移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77984, encryptionId=c40ce798412, topicName=细胞移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4724938298, createdName=limedical1982, createdTime=Mon Mar 22 04:03:30 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1681870, encodeId=5a9b16818e01c, content=<a href='/topic/show?id=2fb489882cb' target=_blank style='color:#2F92EE;'>#血细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89882, encryptionId=2fb489882cb, topicName=血细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a79127868468, createdName=ailian1211, createdTime=Sun May 10 15:03:30 CST 2020, time=2020-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316378, encodeId=ecb813163e8d0, content=<a href='/topic/show?id=f3789349c3' target=_blank style='color:#2F92EE;'>#ICH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9349, encryptionId=f3789349c3, topicName=ICH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431815, encodeId=321b143181584, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469419, encodeId=2430146941985, content=<a href='/topic/show?id=9d6522e613' target=_blank style='color:#2F92EE;'>#ALD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2276, encryptionId=9d6522e613, topicName=ALD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64f67025397, createdName=zhangjingnwpu, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494723, encodeId=04ca1494e234f, content=<a href='/topic/show?id=084d9499599' target=_blank style='color:#2F92EE;'>#造血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94995, encryptionId=084d9499599, topicName=造血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=caed9138962, createdName=俅侠, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621139, encodeId=99f116211394c, content=<a href='/topic/show?id=6ba69501350' target=_blank style='color:#2F92EE;'>#造血细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95013, encryptionId=6ba69501350, topicName=造血细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d6e720195877, createdName=lq1774, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=)]
    2020-04-20 zhangjingnwpu

    #ALD#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1668903, encodeId=5d6116689031c, content=<a href='/topic/show?id=227518e107b' target=_blank style='color:#2F92EE;'>#Wiskott-Aldrich综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18710, encryptionId=227518e107b, topicName=Wiskott-Aldrich综合征)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ffcc26471069, createdName=guojianrong, createdTime=Thu Jul 02 12:03:30 CST 2020, time=2020-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1658930, encodeId=62d516589309c, content=<a href='/topic/show?id=c40ce798412' target=_blank style='color:#2F92EE;'>#细胞移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77984, encryptionId=c40ce798412, topicName=细胞移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4724938298, createdName=limedical1982, createdTime=Mon Mar 22 04:03:30 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1681870, encodeId=5a9b16818e01c, content=<a href='/topic/show?id=2fb489882cb' target=_blank style='color:#2F92EE;'>#血细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89882, encryptionId=2fb489882cb, topicName=血细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a79127868468, createdName=ailian1211, createdTime=Sun May 10 15:03:30 CST 2020, time=2020-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316378, encodeId=ecb813163e8d0, content=<a href='/topic/show?id=f3789349c3' target=_blank style='color:#2F92EE;'>#ICH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9349, encryptionId=f3789349c3, topicName=ICH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431815, encodeId=321b143181584, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469419, encodeId=2430146941985, content=<a href='/topic/show?id=9d6522e613' target=_blank style='color:#2F92EE;'>#ALD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2276, encryptionId=9d6522e613, topicName=ALD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64f67025397, createdName=zhangjingnwpu, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494723, encodeId=04ca1494e234f, content=<a href='/topic/show?id=084d9499599' target=_blank style='color:#2F92EE;'>#造血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94995, encryptionId=084d9499599, topicName=造血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=caed9138962, createdName=俅侠, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621139, encodeId=99f116211394c, content=<a href='/topic/show?id=6ba69501350' target=_blank style='color:#2F92EE;'>#造血细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95013, encryptionId=6ba69501350, topicName=造血细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d6e720195877, createdName=lq1774, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=)]
    2020-04-20 俅侠

    #造血#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1668903, encodeId=5d6116689031c, content=<a href='/topic/show?id=227518e107b' target=_blank style='color:#2F92EE;'>#Wiskott-Aldrich综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18710, encryptionId=227518e107b, topicName=Wiskott-Aldrich综合征)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ffcc26471069, createdName=guojianrong, createdTime=Thu Jul 02 12:03:30 CST 2020, time=2020-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1658930, encodeId=62d516589309c, content=<a href='/topic/show?id=c40ce798412' target=_blank style='color:#2F92EE;'>#细胞移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77984, encryptionId=c40ce798412, topicName=细胞移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4724938298, createdName=limedical1982, createdTime=Mon Mar 22 04:03:30 CST 2021, time=2021-03-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1681870, encodeId=5a9b16818e01c, content=<a href='/topic/show?id=2fb489882cb' target=_blank style='color:#2F92EE;'>#血细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89882, encryptionId=2fb489882cb, topicName=血细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a79127868468, createdName=ailian1211, createdTime=Sun May 10 15:03:30 CST 2020, time=2020-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316378, encodeId=ecb813163e8d0, content=<a href='/topic/show?id=f3789349c3' target=_blank style='color:#2F92EE;'>#ICH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9349, encryptionId=f3789349c3, topicName=ICH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431815, encodeId=321b143181584, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1469419, encodeId=2430146941985, content=<a href='/topic/show?id=9d6522e613' target=_blank style='color:#2F92EE;'>#ALD#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2276, encryptionId=9d6522e613, topicName=ALD)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64f67025397, createdName=zhangjingnwpu, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494723, encodeId=04ca1494e234f, content=<a href='/topic/show?id=084d9499599' target=_blank style='color:#2F92EE;'>#造血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94995, encryptionId=084d9499599, topicName=造血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=caed9138962, createdName=俅侠, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621139, encodeId=99f116211394c, content=<a href='/topic/show?id=6ba69501350' target=_blank style='color:#2F92EE;'>#造血细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95013, encryptionId=6ba69501350, topicName=造血细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d6e720195877, createdName=lq1774, createdTime=Mon Apr 20 15:03:30 CST 2020, time=2020-04-20, status=1, ipAttribution=)]
    2020-04-20 lq1774

    #造血细胞#

    0

相关资讯

2019 ACOG实践简报：妊娠期血小板减少症（No.207）

2019年3月，美国妇产科医师学会(ACOG)发布了妊娠期血小板减少症管理实践指南，妊娠期血小板减少可有多种生理或病理机制引起，本文主要针对妊娠期血小板减少症的检查，诊断，管理等相关内容提出指导建议。

Blood：转录因子IKZF5突变导致血小板减少

中心点：转录因子IKZF5突变可引发常染色体显性遗传的血小板减少症和α颗粒缺乏。虽然IKZF5在造血系细胞中表达，但IKZF5表达失调仅限于巨核细胞系。摘要：为选择遗传性血小板减少症的新发病因，研究人员对NIHR BioResource招募的13 037位个体的全基因组测序（WGS）信息进行遗传关联分析，其中包括233例孤立性血小板减少症。研究人员发现转录因子编码基因IKZF5上的稀有突变与血小板

Blood：多种受体酪氨酸激酶信号介导急性血小板减少时的造血干细胞反应

虽然骨髓（BM）壁龛细胞对于造血干细胞（HSC）的维持至关重要，但应激时，他们之间的相互作用尚不明确。Ramasz等人利用急性血小板减少症的小鼠模型来研究HSCs和壁龛细胞在血小板池恢复过程中的相互作用。

遇见EDTA依赖的血小板聚集怎么办？

最近在检验工作中遇到好几例肉眼不可见的血小板聚集致血小板计数减少的病人，如下面这个患者，用EDTA抗凝的血常规管查得血小板计数为20（图1），推片发现血小板聚集。（图2）

中国成人重症患者血小板减少诊疗专家共识

血小板是直接参与血块形成和炎症调节的血细胞，血小板减少是重症患者常见的并发症。据统计，入住重症监护病房(intensive care unit，ICU)时成人重症患者的血小板减少发生率可达8.3%~67.6%，在ICU治疗期间血小板减少的发生率可达14%~44%。发生血小板减少的重症患者的出血事件和输血量也显著增加，甚至死亡风险也明显提升。因此，全军重症医学专业委员会重症凝血学组联合中华医学会检验

肝素诱导的血小板减少，你了解多少？

抗磷脂综合征（APS）的孕妇需要接受低分子肝素治疗，由于肝素有诱导血小板减少的副作用，同时APS本身也可以导致血小板减少，因此，当接受肝素治疗的APS患者发生血小板减少时需要鉴别究竟是疾病本身所致还是药物所致，这对于后续的治疗至关重要。本文主要对肝素诱导的血小板减少（HIT）及抗磷脂综合征的相关性以及二者的鉴别进行总结。