Clin Gastroenterology H: 炎症性肠病住院患者的体质虚弱与死亡率和再入院率独立相关

2021-09-25 MedSci原创 MedSci原创

老年人 IBD 的发病率和患病率正在上升,60 岁以上的个体中IBD新发病率高达 18.9/100,000。预计在未来十年内,超过1/3 的 IBD 患者是老年人。

      老年人 IBD 的发病率和患病率正在上升,60 岁以上的个体中IBD新发病率高达 18.9/100,000。预计在未来十年内,超过1/3 的 IBD 患者是老年患者。老年 IBD 患者住院率较高、住院死亡率较高、重症感染较高、会有更长的住院时间和住院费用。因此,我们需要重视识别与疾病相关的高危患者,并早期使用生物制剂治疗并发症。虚弱代表一种易受外部和内部压力因素影响的动态状态,并与一些患者的住院和死亡风险增加有关,最近,Kochar 及其同事确定了虚弱是作为生物制剂治疗的 IBD 患者严重感染的独立预测因子。因此,本项研究旨在评估虚弱对 IBD 患者的负担、成本和住院原因的独立影响。

 

      研究人员收集并确定了 2013 年 1 月至 6 月住院并随访至 2013 年 12 月 31 日的 47402 名IBD患者。其中15507 名患者被认为是虚弱的,然后评估了虚弱对疾病负担和住院费用、住院死亡率、再入院和手术风险以及再入院原因的独立影响。

 

      在 10 个月的中位随访时间内,校正年龄、性别、收入、合并症指数、抑郁症、肥胖症、严重程度和指数住院指征后,虚弱与死亡风险升高 57% 独立相关([aHR],1.57;95% CI,1.34–1.83),全因再入院风险增加 21%([HR],1.21;95% CI,1.17–1.25),重度 IBD再入院风险增加 22%(aHR,1.22;95% CI,1.16-1.29)。体弱的 IBD 患者每年住院天数更多(中位数 9 天,非体弱患者的中位数为 5 天;P< .01) 和住院费用较高($17,791 VS  $10,924;P < .01)有关。

 

      本项研究证实虚弱与 IBD 患者较高的死亡率和住院负担独立相关;感染是住院的主要原因。

 

 

原始出处:

Alexander S. Qian. Et al. Frailty Is Independently Associated with Mortality and Readmission in Hospitalized Patients with Inflammatory Bowel Diseases.Clinical Gastroenterology Hepatology.2021.

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    2021-09-26 许安
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    2021-10-04 1def6e10m76(暂无匿称)

    本项研究证实虚弱与 IBD 患者较高的死亡率和住院负担独立相关;感染是住院的主要原因

    0

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