Am J Gastroenterol:吸烟对克罗恩疾病复发的影响

2016-02-16 Mechront 译 MedSci原创

吸烟是与克罗恩疾病(CD)密切相关的环境因素。研究者进行了一项研究,探究当前吸烟对CD复发的影响,以及抗TNF药物和免疫抑制剂治疗CD过程中,戒烟对疗效的影响。该前瞻性多中心队列研究纳入了573名CD缓解期患者,所有患者均被建议戒烟。在随访的4年时间里,比较了不同吸烟情况患者的疾病预后差异。参与者中有148名患者继续吸烟,190名非吸烟者,160名曾经吸烟的患者,还有75名戒烟者。研究数据显示,与

吸烟是与克罗恩疾病(CD)密切相关的环境因素。研究者进行了一项研究,探究当前吸烟对CD复发的影响,以及抗TNF药物和免疫抑制剂治疗CD过程中,戒烟对疗效的影响。

该前瞻性多中心队列研究纳入了573名CD缓解期患者,所有患者均被建议戒烟。在随访的4年时间里,比较了不同吸烟情况患者的疾病预后差异。

参与者中有148名患者继续吸烟,190名非吸烟者,160名曾经吸烟的患者,还有75名戒烟者。研究数据显示,与非吸烟者相比,继续吸烟的患者疾病发生更频繁(OR=1.53,95% CI: 1.10-2.17)。曾吸烟、戒烟者和非吸烟者相比,疾病复发无差异。多因素分析显示,吸烟是疾病复发的独立预测因素(HR=1.58,95% CI:1.20-2.09)。随时间变化的分析显示,不管有没有进行治疗,继续吸烟的患者会更早的出现疾病复发。

研究结果表明,继续吸烟的CD患者更容易复发,戒烟后疾病复发风险与非吸烟者类似。

原始出处:


Nunes T, Etchevers MJ,et al.Impact of Smoking Cessation on the Clinical Course of Crohn's Disease Under Current Therapeutic Algorithms: A Multicenter Prospective Study.Am J Gastroenterol. 2016 Feb 9. doi: 10.1038/ajg.2015.401. 


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