Front Cell Neurosci：妊娠中期接触七氟醚对幼鼠学习和记忆的影响：母体锻炼的有益作用

2018-08-12 余晓旭罂粟花

胎儿接触全身麻醉药物可能会有严重的神经认知风险，但是减轻这些有害影响的方法仍不清楚。因此，我们开始评估在大鼠怀孕期间单次或重复接触七氟醚是否会引发大鼠后代的长期认知障碍。由于怀孕期间的母体锻炼已经证明可以改善后代的认知能力，我们假设怀孕期间的母体通过跑步机锻炼可以预防由七氟醚-诱发的神经毒性。

背景与目的

胎儿接触全身麻醉药物可能会有严重的神经认知风险，但是减轻这些有害影响的方法仍不清楚。因此，我们开始评估在大鼠怀孕期间单次或重复接触七氟醚是否会引发大鼠后代的长期认知障碍。由于怀孕期间的母体锻炼已经证明可以改善后代的认知能力，我们假设怀孕期间的母体通过跑步机锻炼可以预防由七氟醚-诱发的神经毒性。

方法

在第一个实验中，怀孕大鼠在妊娠期（G）第14天的时候吸入3%的七氟醚2h，或者连续在G13、G14和G15天时吸入七氟醚2 h。在第二个实验中，整个怀孕期间，运动组的妊娠大鼠每天强制在跑步机上跑60分钟。使用TrkB的拮抗剂ANA-12来研究脑源性神经营养因子（BDNF）/TrkB/akt信号通路是否与母体运动所提供的神经保护有关。

结果

我们的数据表明重复吸入七氟醚，会导致胎儿大脑组织和出生后幼鼠的海马体中的组蛋白乙酰化和BDNF表达减少。还会导致树突棘数量减少，空间依赖性学习和记忆功能障碍。这些影响通过母体的运动得到了缓解，但TrkB的拮抗剂ANA-12消除了母体运动的有益影响。

结论

在妊娠中期的大鼠重复吸入七氟醚会导致后代长期的学习和记忆功能障碍。母鼠运动后通过加强组蛋白乙酰化和激活BDNF/TrkB/Akt下游信号，减轻幼鼠神经认知障碍。

原始出处：

Wu Z， Li X， Zhang Y， et al. Effects of Sevoflurane Exposure During Mid-Pregnancy on Learning and Memory in Offspring Rats： Beneficial Effects of Maternal Exercise[J]. Frontiers in Cellular Neuroscience， 2018， 12.

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#插入话题

插入图片

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2019-05-17 zhaozhouchifen

#Cell#

25 0
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2018-10-15 维他命

#CEL#

23 0
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2018-08-14 lsndxfj

#ROS#

25 0
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2018-08-14 linagood

#七氟醚#

46 0
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2018-08-12 jingjing

运动锻炼应该是健康第一要素，对各类疾病都应该有益。但是国内这方面研究太少

35 0
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2018-08-12 天地飞扬

了解一下，谢谢分享！

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