J Periodontol:唾液和血清中的不对称二甲基精氨酸(ADMA)水平是否能作为心血管风险的评价指标?

2020-08-23 MedSci原创 MedSci原创

不对称二甲基精氨酸(ADMA)在内皮功能中起着至关重要的作用,也许是已知的牙周炎和冠心病(CHD)相互作用的一个环节。

不对称二甲基精氨酸(ADMA)在内皮功能中至关重要,可能在牙周炎和冠心病(CHD)的相互作用中发挥着重要作用。本研究比较了牙龈健康、牙周炎(CP)、CHD或两种疾病(CP+CHD)对唾液和血清ADMA水平的影响。

研究纳入35名健康受试者,35名CP患者、33名CHD患者以及35名同时患有CP和CHD的患者,收集参与者的临床和牙周参数、血清和唾液样本。检测ADMA和C反应蛋白(CRP)的水平。

结果发现,与CP患者和对照组相比,CHD组和CP+CHD组的唾液和血清ADMA浓度中位数(25%和75%百分位数)显著升高,分别为[血清 1.5(1.2~1.8)μmol/L;唾液1.3(1~1.7)μmol/g蛋白,P<0.01],[血清:1.8(1.4~2.0)μmol/L;唾液1.3(1~1.7)μmol/g蛋白,P<0.01]。在单变量模型中,CP,CHD和hs-CRP与血清ADMA显著相关,并且在多变量模型中,hs-CRP仍是血清ADMA的显著预测因子。多变量模型中,唾液ADMA水平的显著预测因素是hs-CRP和教育社会经济地位。

因此,与健康人和CP患者相比,CHD和CP+CHD患者的唾液和血清ADMA水平较高,hs-CRP是唾液和血清ADMA水平增加的重要预测因子。

原文出处:

Gaetano Isola,Evaluation of salivary and serum asymmetric dimethylarginine (ADMA) levels in patients with periodontal and cardiovascular disease as subclinical marker of cardiovascular risk,Journal of Periodontology,2020,8.

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    2021-06-15 feather89
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    2020-08-25 huagfeg

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