JACC:PET可以预测心肌淀粉样变性患者的预后

2020-02-14 不详 MedSci原创

目前,对于心肌淀粉样沉积程度的非侵入性评估是否能预测轻链(AL)心肌淀粉样变性患者的预后尚不清楚。本研究的目的旨在评估11C-PiB PET是否能预测AL心肌淀粉样变性的预后。本研究纳入分析了41名AL心肌淀粉样变性患者,主要终点事件是全因死亡、心脏移植和急性心衰的复合事件。分析结果显示,相比于对照,11C-PiB PET的摄入在心肌淀粉样变性患者中更高,并与免疫组化的淀粉沉积程度相符。在平均42

目前,对于心肌淀粉样沉积程度的非侵入性评估是否能预测轻链(AL)心肌淀粉样变性患者的预后尚不清楚。本研究的目的旨在评估11C-PiB PET是否能预测AL心肌淀粉样变性的预后。

本研究纳入分析了41名AL心肌淀粉样变性患者,主要终点事件是全因死亡、心脏移植和急性心衰的复合事件。分析结果显示,相比于对照,11C-PiB PET的摄入在心肌淀粉样变性患者中更高,并与免疫组化的淀粉沉积程度相符。在平均423天的随访时间里,24名患者发生了主要终点事件。11C-PiB PET的摄入越高的患者生存率越低,多变量回归分析模型中,11C-PiB PET的摄入量是心肌淀粉样变性患者预后的独立预测因子。

研究结果显示,心肌淀粉沉积的非侵入性评估可以真实反映AL心肌淀粉样变性患者的心肌淀粉沉积程度,是患者预后的独立预测因子。

原始出处:

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    2020-08-14 feather89
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    2020-10-28 hbwxf
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    2020-02-16 huangdf

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