J Peiodontal Res: FOXP3+和CD25+细胞在IV-C型牙周炎患者中减少

2020-06-05 网络 网络

一些研究提出,调节性T细胞(Tregs)对炎症性骨吸收具有抑制作用。本研究旨在评估牙周炎患者炎症组织中的Treg免疫标志物。

一些研究提出,调节性T细胞(Tregs)对炎症性骨吸收具有抑制作用。本研究旨在评估牙周炎患者炎症组织中的Treg免疫标志物。

研究共纳入30名参与者,分为3组,IV期、C级牙周炎(IV-C);III期、B级牙周炎(III-B)和对照组参与者(每组10名),检测牙周组织上皮和固有层中CD4、CD25和FOXP3(Treg免疫标志物)阳性细胞的存在和分布情况。采用Fisher's LSD检验后的双因素方差分析分析组间的差异和免疫标志物的差异;采用Student's t检验来检测上皮和固有层之间的差异。

结果发现, IV-C和III-B型牙周炎组的免疫标记细胞均呈现高比例,与对照组具有统计学差异。并且,III-B型牙周炎中检测到的CD25+和FOXP3+细胞数量明显高于IV-C型牙周炎(P<0.05)。

结果提示,Tregs可能参与IV-C和III-B型牙周炎患者的骨免疫机制,对牙槽骨再生的临床应用具有一定的帮助。

原文出处:

Raphael J. G. da Motta,FOXP3+ and CD25+ cells are reduced in patients with stage IV, grade C periodontitis: A comparative clinical study,journal of periodontal research,2020 June ,doi: 10.1111/jre.12721

 

 

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    2021-03-01 陈吴1234
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    2020-09-24 zhs3890
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    2020-08-26 feather89
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