JACC Cardiovasc Interv:英国研究称肺动脉去神经治疗肺动脉高压安全有效!

2020-04-29 卢芳 中国循环杂志

肺动脉高压不好治,靶向药物也贵,还有什么好办法治疗吗?

肺动脉高压不好治,靶向药物也贵,还有什么好办法治疗吗?

近日,发表在JACC子刊上的一项英国研究显示,血管内超声指引下的肺动脉去神经治疗安全有效。

研究者认为,这种治疗方法或提供了药物治疗的替代升级治疗或联合治疗手段。

研究显示,接受肺动脉去神经治疗的23例肺动脉高压患者,均未发生手术相关的严重不良事件。

随访4个月和6个月时,患者肺血管阻抗下降17.8%,6分钟步行距离平均增加42米,日常活动增加了671步。

其中,14例患者肺血管阻抗较基线水平降低多于10%,其中8例降低多于20%。

研究还显示,患者平均肺动脉压、右心房压和肺动脉顺应性均显着改善。

随访期间,有6例患者发生临床恶化事件。

TROPHY1共纳入8个医疗中心18~75岁双联或三联口服药物治疗,且对急性肺血管舒张试验无反应的23例肺动脉高压患者。研究期间,患者持续服用上述药物。

原始出处:Rothman AMK, Vachiery JL, Howard LS, et al. Intravascular Ultrasound Pulmonary Artery Denervation to Treat Pulmonary Arterial Hypertension (TROPHY1): Multicenter, Early Feasibility Study.JACC Cardiovasc Interv. 2020 Apr 27;13(8):989-999.

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    2021-03-04 hbwxf
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    2021-02-11 quxin068
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    2020-04-29 明天jing

    肺动脉高压表面是罕见病,事实上临床上并不少见,治疗药物虽然有一些,但是整体仍然不理解,可能未来需要采用综合治疗措施。

    0

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