Int J Cancer:咖啡和绿茶真的能降低急性髓系白血病和骨髓增生异常综合征的风险吗?

2017-10-31 MedSci MedSci原创

尽管先前的研究建议喝咖啡和绿茶可以降低某些癌症的风险,但只有少数流行病学研究调查了它们对急性髓系白血病(AML)风险和骨髓增生异常综合征(MDS)风险的影响。

尽管先前的研究建议喝咖啡和绿茶可以降低某些癌症的风险,但只有少数流行病学研究调查了它们对急性髓系白血病(AML)风险和骨髓增生异常综合征(MDS)风险的影响。

本研究中,来自日本的研究人员在日本大规模人群队列研究中调查了咖啡和绿茶消费量与AML风险和MDS风险的相关性。

研究共纳入了95807个日本参与者(其中,45937名为男性,49870名为女性;基线年龄在40-69岁之间),研究人员对他们随访至2012年底,平均随访时间为18年。研究人员使用Cox比例风险模型对潜在混杂因素进行调整后,评估了基线时咖啡和绿茶的消费量与AML风险和MDS风险之间相关性,并统计了其危险比(HRS)和95%可信区间(95% CI)。

在1751.956人-年的随访中,研究人员确定了85例AML患者和70例MDS患者。研究结果表明,咖啡消费与AML风险、绿茶消费与AML/MDS风险之间没有显著相关性。与此相反,研究人员在咖啡消费和男性MDS风险之间观察到了一个下降的剂量-反应关系(几乎没有:对照;1-4次/周:HR = 0.83,95%可信区间:0.43-1.62;≥1杯/天:HR = 0.47,0.22-0.99,趋势P = 0.049)。吸烟状态的分层分析表明,相对于非咖啡饮用者,咖啡饮用者与AML和MDS的相对危险性可能是由吸烟引起的残余混杂造成的。

不论怎么说,这些发现都值得进一步研究。

原始出处:

Ugai T, Matsuo K,et al.Coffee and green tea consumption and subsequent risk of acute myeloid leukemia and myelodysplastic syndromes in Japan.Int J Cancer. 2017 Oct 27. doi: 10.1002/ijc.31135. [Epub ahead of print]

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    2017-11-02 hbwxf
  6. 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likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Wed Nov 01 07:25:30 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257699, encodeId=9fe625e6996a, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Wed Nov 01 07:25:23 CST 2017, time=2017-11-01, status=1, ipAttribution=)]
    2017-11-01 李东泽

    是很好的学习材料.不错.以后会多学习.

    0

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likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Wed Nov 01 07:25:30 CST 2017, time=2017-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=257699, encodeId=9fe625e6996a, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Pw2csslt7CukWiabqiblnQAXaDEiaxhu025c3P0XshccTrbvGWBjKvnHIxbK3vqa80P7WGIFuicCFet97TicrNKpgB3TdabxP1vMh/0, createdBy=28851960965, createdName=榄枷檬, createdTime=Wed Nov 01 07:25:23 CST 2017, time=2017-11-01, status=1, ipAttribution=)]
    2017-11-01 中医痴

    不错的.学习了.学习分享!

    0

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    2017-11-01 榄枷檬

    谢谢分享

    0

  10. 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    2017-11-01 榄枷檬

    学习学习

    0

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