J Clin Periodontol: 绿茶对长期高血糖T1D大鼠的血管紊乱和牙周破坏的预防作用

2018-05-20 MedSci MedSci原创

评估绿茶对链脲佐菌素诱导的1型糖尿病(T1D)大鼠长期高血糖期间自发性牙周炎进展过程中血管调节的影响。

评估绿茶对链脲佐菌素诱导的1型糖尿病(T1D)大鼠长期高血糖期间自发性牙周炎进展过程中血管调节的影响。

血糖正常(NG)和T1DWistar大鼠分成接受水(NG-W和T1D-W)和绿茶(NG-GT和T1D-GT)的两个实验组和两个对照组。通过显微摄影和组织学分析评估牙周情况。评估VEGF(NcVEGF + / mm2)和CD31(NcCD31 + / mm2)的免疫染色细胞的数量,以及牙周韧带(PDL)中的微血管密度(MVD)。

结果:T1D-W大鼠长期高血糖导致PDL血管改变,MVD降低36%,NcCD31 + / mm2降低33%,NcVEGF + / mm2升高53%。同时,重度牙周炎患者骨量和牙周骨水平降低较多。在T1D-GT中,与正常血糖组类似,绿茶会保持PDL中的MVD,NcCD31 + / mm2和NcVEGF + / mm2。临床上,在T1D-GT大鼠中,与T1D-W相比,绿茶会减少菌斑积聚,减轻牙周炎的程度。

日常饮用绿茶对PDL糖尿病血管病变和T1D大鼠长期高血糖患者牙周炎发展具有治疗作用。

原始出处:

Daniela Pereira Catanzaro, et al. Green tea prevents vascular disturbs and attenuates periodontal breakdown in long‐term hyperglycaemia in T1D rats. Journal of Clinical Periodontology. 2018 May. doi:10.1111/jcpe.12883

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    2018-08-27 feather89
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    2018-05-22 hbwxf
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    2018-05-22 hbwxf
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    2018-05-22 huhuaidong391

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