Neurology:癫痫和痴呆之间的双向关联

2020-10-25 MedSci原创 MedSci原创

癫痫和痴呆之间存在双向关联,与对照者相比,这两种疾病患者发生另一种疾病的风险接近2倍。

近日,神经病学领域权威杂志Neurology上发表了一篇研究文章,该研究旨在评估弗雷明汉心脏研究(FHS)中痴呆症参与者发生癫痫的风险,以及癫痫患者中发生痴呆的风险。

研究人员分析了FHS第一代和子代队列中前瞻性收集的数据。为了确定患有痴呆症参与者发生癫痫的风险和患有癫痫的参与者发生痴呆的风险,研究人员使用了单独的、嵌套的病例对照设计,并将每个病例与3个年龄、性别和FHS队列匹配的对照者进行匹配。研究人员使用Cox比例风险回归分析,根据性别和年龄进行了调整。在次要分析中,研究人员调查了教育水平和载脂蛋白ε4等位基因状态在调节癫痫和痴呆之间的关系中的作用。

该研究共对4906名参与者65岁以后进行了癫痫和痴呆症信息收集以及痴呆症随访。在660名患有痴呆症的参与者和1980名无痴呆对照者中,58例参与者发生了癫痫发作。痴呆病例与对照组之间比较癫痫风险的分析得出HR=1.82 [95%CI:1.05-3.16],p=0.034。在43名癫痫患者和129名无癫痫对照者中,有51名发生痴呆症。在癫痫病例与对照组之间比较痴呆风险的分析得出HR=1.99 [1.11-3.57],p=0.021。在这一病例组中,接受过任何高中教育的参与者中,与具有相同教育水平的对照者相比,癫痫患者发生痴呆症的风险升高接近5倍(HR=4.67 [1.82-12.01],p=0.001) 。

由此可见,癫痫和痴呆之间存在双向关联,与对照者相比,这两种疾病患者发生另一种疾病的风险接近2倍。

原始出处:

Maria Stefanidou.et al.The bi-directional association between epilepsy and dementia. The Framingham Heart Study.Neurology.2020.https://n.neurology.org/content/early/2020/10/23/WNL.0000000000011077

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    2021-07-21 yinhl1978
  2. [GetPortalCommentsPageByObjectIdResponse(id=2001126, encodeId=65cc2001126fc, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Jul 21 05:14:05 CST 2021, time=2021-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894579, encodeId=ad3f8945e993, content=癫痫和痴呆之间存在双向关联,与对照者相比,这两种疾病患者发生另一种疾病的风险接近2倍。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Oct 26 17:45:24 CST 2020, time=2020-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894552, encodeId=57b78945521f, content=癫痫发一次病就损害一批脑细胞,当然会变傻<a href='/topic/show?id=54068020409' target=_blank style='color:#2F92EE;'>#老年痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=282, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80204, encryptionId=54068020409, topicName=老年痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210607/9f00a0de660e4b36b77a9a5f7620d6bf/98c22b17ddf7446fa7b9a618fabcb9f7.jpg, createdBy=a8fb2299762, createdName=Psycho.Dr Du, createdTime=Mon Oct 26 16:14:42 CST 2020, time=2020-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894426, encodeId=be23894426a2, content=这个研究有意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201025/6855c11d03d14ffe9821c390a8212f6a/4a122e6cdf4f4857a3a1ced2063770bd.jpg, createdBy=0ce587510, createdName=narutohokage, createdTime=Sun Oct 25 22:33:48 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048678, encodeId=d3eb10486e885, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Sun Oct 25 18:14:05 CST 2020, time=2020-10-25, status=1, ipAttribution=)]
    2020-10-26 Jessica

    癫痫和痴呆之间存在双向关联,与对照者相比,这两种疾病患者发生另一种疾病的风险接近2倍。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2001126, encodeId=65cc2001126fc, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Jul 21 05:14:05 CST 2021, time=2021-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894579, encodeId=ad3f8945e993, content=癫痫和痴呆之间存在双向关联,与对照者相比,这两种疾病患者发生另一种疾病的风险接近2倍。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Oct 26 17:45:24 CST 2020, time=2020-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894552, encodeId=57b78945521f, content=癫痫发一次病就损害一批脑细胞,当然会变傻<a href='/topic/show?id=54068020409' target=_blank style='color:#2F92EE;'>#老年痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=282, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80204, encryptionId=54068020409, topicName=老年痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210607/9f00a0de660e4b36b77a9a5f7620d6bf/98c22b17ddf7446fa7b9a618fabcb9f7.jpg, createdBy=a8fb2299762, createdName=Psycho.Dr Du, createdTime=Mon Oct 26 16:14:42 CST 2020, time=2020-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894426, encodeId=be23894426a2, content=这个研究有意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201025/6855c11d03d14ffe9821c390a8212f6a/4a122e6cdf4f4857a3a1ced2063770bd.jpg, createdBy=0ce587510, createdName=narutohokage, createdTime=Sun Oct 25 22:33:48 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048678, encodeId=d3eb10486e885, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Sun Oct 25 18:14:05 CST 2020, time=2020-10-25, status=1, ipAttribution=)]
    2020-10-26 Psycho.Dr Du

    癫痫发一次病就损害一批脑细胞,当然会变傻#老年痴呆症#

    0

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    2020-10-25 narutohokage

    这个研究有意义

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2001126, encodeId=65cc2001126fc, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Jul 21 05:14:05 CST 2021, time=2021-07-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894579, encodeId=ad3f8945e993, content=癫痫和痴呆之间存在双向关联,与对照者相比,这两种疾病患者发生另一种疾病的风险接近2倍。 , beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Oct 26 17:45:24 CST 2020, time=2020-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894552, encodeId=57b78945521f, content=癫痫发一次病就损害一批脑细胞,当然会变傻<a href='/topic/show?id=54068020409' target=_blank style='color:#2F92EE;'>#老年痴呆症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=282, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80204, encryptionId=54068020409, topicName=老年痴呆症)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210607/9f00a0de660e4b36b77a9a5f7620d6bf/98c22b17ddf7446fa7b9a618fabcb9f7.jpg, createdBy=a8fb2299762, createdName=Psycho.Dr Du, createdTime=Mon Oct 26 16:14:42 CST 2020, time=2020-10-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894426, encodeId=be23894426a2, content=这个研究有意义, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201025/6855c11d03d14ffe9821c390a8212f6a/4a122e6cdf4f4857a3a1ced2063770bd.jpg, createdBy=0ce587510, createdName=narutohokage, createdTime=Sun Oct 25 22:33:48 CST 2020, time=2020-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048678, encodeId=d3eb10486e885, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Sun Oct 25 18:14:05 CST 2020, time=2020-10-25, status=1, ipAttribution=)]
    2020-10-25 junJUN

    老年人痴呆何药可用??

    0

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