JCEM:新冠疫情期间儿童和青少年2型糖尿病趋势的变化

2022-04-14 从医路漫漫 MedSci原创

随着疫情的持续,据报道,青少年新发T2D住院率增加,诊断为小儿T2D的糖尿病酮症酸中毒发生率更高。儿童T2D的发病率和严重程度似乎都在增加,即使在没有新冠肺炎感染的人群中也是如此。

背景:在新冠肺炎疫情之前,二型糖尿病(T2D)在儿科人群中的患病率正在增加。随着新冠肺炎疫情的出现,年轻人的日常生活发生了巨大的变化,许多家庭失去了收入。随着疫情的持续,据报道,青少年新发T2D住院率增加,诊断为小儿T2D的糖尿病酮症酸中毒发生率更高。儿童T2D的发病率和严重程度似乎都在增加,即使在没有新冠肺炎感染的人群中也是如此。了解新冠肺炎疫情对小儿T2D的全面影响至关重要,因此需要更多的研究。迄今为止,大部分文献都是针对儿科T2D住院患者的,仅针对新发T2D患者的一个子集。

我们通过调查阿拉巴马州新发小儿T2D的发生趋势,包括需要住院治疗和门诊治疗的儿童,以及这些趋势如何随着COVID19疫情的发作而变化,从而为证据做出贡献。像其他东南部各州一样,阿拉巴马州的非西班牙裔黑人(NHB)人口比例较高,贫困率、肥胖率和糖尿病率较高,并且在健康指标上的得分相对于其他州较低。为了评估新冠肺炎疫情对这个高风险州人口的潜在影响,我们使用了阿拉巴马州儿童医院(COA)的数据,该州大约90%的T2D儿童和青少年在该医院接受医疗护理。我们还研究了新冠肺炎疫情之前和期间新发T2D患者的人口统计学特征和健康指标的差异。最后,我们研究了疫情期间医疗补助患者相对于其他形式保险(以下简称非医疗补助)患者的变化。阿拉巴马州大约53%的儿童加入了医疗补助计划,该计划涵盖了低于联邦贫困线146%的家庭的儿童;38.1%的医疗补助参保者是NHB人,43.6%是非西班牙裔白人(NHW)。

目的:研究新发儿科二型糖尿病(T2D)的趋势(包括需要住院治疗的患者和门诊管理的患者)是否在新冠肺炎疫情期间受到影响,并比较新冠肺炎之前和期间的患者特征。

方法:回顾性单中心医疗记录回顾在一所医院进行,该医院护理了阿拉巴马州90%的儿童T2D患者。纳入了2017年3月至2021年3月期间转诊的新发T2D患者。计算每月就诊的患者数。线性回归模型对整个样本进行估计,并根据医疗补助和非医疗补助保险状况进行分层。比较了新冠肺炎术前和术中患者的特征。

结果:642名患者在此期间出现新发T2D。COVID19之前的月死亡率为11.1±3.8,新冠肺炎期间为19.3±7.8(p = 0.004)。在新冠肺炎之前和期间,医疗补助患者的月费率不同(7.9±3.4比15.3±6.6,p = 0.003),但非医疗补助患者的月费率没有差异(3.3±1.7比4.0±2.4,p=0.33)。回归结果显示,在新冠肺炎期间,全部样本(β=,p<0.05)和医疗补助登记者(β=,p<0.05)的月比率显著增加。住院率、肥胖严重程度和血红蛋白A1c在新冠肺炎之前和期间保持相似,尽管男性患者的比例从36.8%增加到46.1% (p=0.021)。

表1:每月COVID案例的最小二乘回归结果

表2 前新冠肺炎疫情和新冠肺炎疫情时期患者的社会人口统计学和临床特征的差异

图1:所有患者、医疗补助患者和非医疗补助患者的月费用观察值。

结论:在新冠肺炎疫情期间,在阿拉巴马州的年轻人中观察到新发T2D的增加,这一负担不成比例地影响了医疗补助登记者和男性。未来的研究应该探索疫情影响儿科T2D的途径。

原文出处:Schmitt JA,  Ashraf AP,  Becker DJ,  Sen B,Changes in Type 2 diabetes trends in Children and Adolescents during the COVID-19 Pandemic.J Clin Endocrinol Metab 2022 Apr 04

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    2022-04-27 achengzhao
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    2022-08-13 smallant2015
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    2022-04-14 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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    2022-04-14 ms7000000682486447

    0

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    2022-04-15 xulv123

    认真学习~~

    0

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    2022-04-15 西瓜0628

    学习了#学习#

    0

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    2022-04-15 学医无涯

    学习一下

    0

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