J Rheumatol:系统性红斑狼疮患者骨坏死的监测

2018-07-09 xiangting MedSci原创

根据现有最佳证据,使用糖皮质激素与SLE患者的ON密切相关。

非创伤性骨坏死(ON)是一种公认的、可导致残疾并影响系统性红斑狼疮(SLE)患者生活质量的并发症。这项研究目的是确定ON的危险因素,并确定最佳监测SLE患者ON风险所需的最小限度调查。

研究人员使用MEDLINE和EMBASE进行系统评价。使用医学主题词表(MeSH)术语"骨坏死"、"系统性红斑狼疮"和同义词检索这些数据库2016年1月以前的文献。纳入随机对照试验、病例对照、队列和横断面研究。汇总了SLE患者ON的危险因素。使用纽卡斯尔-渥太华评分评估非随机研究的质量。使用建议、评估、制定和评价的分级法评估每个风险因素的证据质量。

在545个参考文献中,50个符合纳入标准。使用糖皮质激素(CS)与SLE患者的ON呈强相关。其他临床变量中度相关,其中包括高血压、浆膜炎、肾病、血管炎、关节炎和中枢神经系统疾病。然而,证据质量低甚至很低。

根据现有最佳证据,使用糖皮质激素与SLE患者的ON密切相关。在制定加拿大SLE患者诊断监测建议时考虑了该项评价的结果,这将指导临床医生对患者的评估。

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    2019-02-08 zll0634
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    2018-07-11 millore
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    2018-07-11 zhouqu_8

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