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Circulation：AnxA1可调控血小板功能、促进炎症消融！

2019-08-06 MedSci MedSci原创

AnxA1缺血再灌注血小板血栓
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缺血再灌注损伤(I/RI)是心血管疾病的常见并发症。处理好有害的I/ RI生成的血栓前和促炎症反应是恢复体内平衡的关键。血小板在血栓形成和炎症的整合中起着至关重要的作用。现研究人员利用药理和遗传学方法，结合小鼠和临床样本，来揭示血小板在血栓炎症中的重要作用。在野生型和AnxA1敲除（AnxA-/-）小鼠中进行大脑中动脉闭塞再灌注处理。用荧光显微镜观察细胞迁移监测光/染料诱导的血栓形成。用空载、An

缺血再灌注损伤(I/RI)是心血管疾病的常见并发症。处理好有害的I/ RI生成的血栓前和促炎症反应是恢复体内平衡的关键。血小板在血栓形成和炎症的整合中起着至关重要的作用。现研究人员利用药理和遗传学方法，结合小鼠和临床样本，来揭示血小板在血栓炎症中的重要作用。

在野生型和AnxA1敲除（AnxA-/-）小鼠中进行大脑中动脉闭塞再灌注处理。用荧光显微镜观察细胞迁移监测光/染料诱导的血栓形成。用空载、AnxA1（3.3mg/kg）、WRW4（1.8mg/kg）或三者来治疗小鼠，检测AnxA1的作用。

静脉镜显示，I/RI后血小板粘附和聚集能力增强，AnxA-/-小鼠表现的更严重。AnxA1直接调控血小板功能(如通过降低血栓素B2和调节磷脂酰丝氨酸表达)，以促进I/RI后的大脑保护，并通过降低血小板的活化、聚集和脑血栓形成来有效预防中风。此外，研究人员还发现人和小鼠中风时，血浆AnxA1水平降低，AnxA1可以作用于人血小板，抑制经典的血栓诱导的由内向外的信号事件（如Akt激活），来减少αIIbβ3激活，而且不影响其表面表达。AnxA1还可以选择性的介导细胞表面决定簇（如磷脂酰丝氨酸），通过中性粒细胞来促进血小板吞噬，进而促进血栓分解。

总而言之，AnxA1可通过改变血小板表现来预防大脑I/RI，本研究展示了AnxA1的一个新的作用，即可作为治疗药物，又可作为预防药物，同时也推进了我们对血小板和血栓溶解生理的理解。

原始出处：

Elena Y. Senchenkova， et al.Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation. https：//doi.org/10.1161/CIRCULATIONAHA.118.039345Circulation. 2019；140：319–335

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    2020-01-04 119337457

    #AnxA1#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1779987, encodeId=27901e7998714, content=<a href='/topic/show?id=8d9526090c' target=_blank style='color:#2F92EE;'>#AnxA1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2609, encryptionId=8d9526090c, topicName=AnxA1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Sat Jan 04 00:41:00 CST 2020, time=2020-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421784, encodeId=a36b1421e84ee, content=<a href='/topic/show?id=4bc865819d2' target=_blank style='color:#2F92EE;'>#消融#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65819, encryptionId=4bc865819d2, topicName=消融)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a193676008, createdName=xiangyuzhou972, createdTime=Wed Aug 07 15:41:00 CST 2019, time=2019-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370842, encodeId=b6ed3e0842bd, content=学习学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Tue Aug 06 05:56:52 CST 2019, time=2019-08-06, status=1, ipAttribution=)]
    2019-08-07 xiangyuzhou972

    #消融#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1779987, encodeId=27901e7998714, content=<a href='/topic/show?id=8d9526090c' target=_blank style='color:#2F92EE;'>#AnxA1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2609, encryptionId=8d9526090c, topicName=AnxA1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Sat Jan 04 00:41:00 CST 2020, time=2020-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421784, encodeId=a36b1421e84ee, content=<a href='/topic/show?id=4bc865819d2' target=_blank style='color:#2F92EE;'>#消融#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65819, encryptionId=4bc865819d2, topicName=消融)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a193676008, createdName=xiangyuzhou972, createdTime=Wed Aug 07 15:41:00 CST 2019, time=2019-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=370842, encodeId=b6ed3e0842bd, content=学习学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Tue Aug 06 05:56:52 CST 2019, time=2019-08-06, status=1, ipAttribution=)]
    2019-08-06 深海的鱼

    学习学习学习学习

    0