Brit J Cancer:乳房X线微钙化灶与乳腺癌风险

2021-06-15 MedSci原创 MedSci原创

微钙化灶群是BC的独立危险因素,绝经前妇女的估计风险更高。在绝经后女性中,微钙化灶群与BC之间的关联与基线MD类似。

乳房X线微钙化被认为是乳腺癌 (BC) 的早期迹象。

近日,肿瘤学领域权威杂志British Journal of Cancer上发表了一篇研究文章,研究人员评估了微钙化灶群与整体和亚型特异性BC风险之间的关联。此外,研究人员分析了乳房X线检查结果上密度 (MD) 如何影响微钙化灶与BC风险之间的关联。

研究人员使用了瑞典女性的前瞻性队列 (n = 53,273),这些参与者具有关于BC危险因素和乳房X线检查照片的全面信息。研究人员分别采用计算机辅助检测系统和STRATUS方法测量了微钙化灶的总数和MD。此外,研究人员采用Cox 回归和Logistic回归进行数据分析。

微钙化灶与乳腺癌特点

该研究中总共有676名女性被诊断为BC病例。与没有微钙化灶的女性相比,具有3个以上微钙化灶的女性风险比[HR]为2.17(95%置信区间[CI]=1.57-3.01)。绝经前妇女的估计风险更为明显(HR=2.93;95%CI=1.67-5.16)。对于绝经后妇女,微钙化灶和MD对BC风险有类似的效应。在微钙化灶和MD之间没有观察到相互作用。微钙化灶与原位乳腺癌显著相关(比值比:2.03;95%CI=1.13-3.63)。

由此可见,微钙化灶群是BC的独立危险因素,绝经前妇女的估计风险更高。在绝经后女性中,微钙化灶群与BC之间的关联与基线MD类似

原始出处:

Shadi Azam.et al.Mammographic microcalcifications and risk of breast cancer.Brit J Cancer.2021.https://www.nature.com/articles/s41416-021-01459-x

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    2022-05-30 sjq027
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    2021-06-17 piaojinhua

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