J Korean Med Sci:6-35个月大的韩国儿童中,三价和四价流感疫苗接种后6个月的免疫力下降

2020-09-30 MedSci原创 MedSci原创

流感疫苗引起的抗体滴度随着时间的推移而下降,年龄较小的儿童免疫原性较低,免疫时间较短。本研究旨在根据流感病毒株、疫苗种类、抗原剂量、初效状态比较6~35个月儿童接种流感疫苗后6个月抗体的持久性,研究结

流感疫苗引起的抗体滴度随着时间的推移而下降,年龄较小的儿童免疫原性较低,免疫时间较短。本研究旨在根据流感病毒株、疫苗种类、抗原剂量、初效状态比较6~35个月儿童接种流感疫苗后6个月抗体的持久性,研究结果已在线发表于J Korean Med Sci。

2016年9月至12月研究人员在韩国10家医院共入选124名6~35个月的健康儿童,并随机分配到全剂量的四价流感疫苗或半剂量的维多利亚B株组三价流感疫苗。在接种后6个月评估推荐流感菌株的血凝抑制抗体滴度(衡量血清保护率)。

 

结果显示,甲型H1N1、甲型H3N2、乙型山形和乙型维多利亚在6个月后的血清保护率分别为88.7%、97.4%、36.6%和27.6%。甲型(H1N1)、甲型(H3N2)和乙型(维多利亚)的血清保护率在全剂量四价疫苗中分别为91.4%、98.7%和27.5%,而在半剂量三价疫苗中分别为83.7%、94.6%和27.9%。四价组对B(山形)株的血清保护率为23.8%,三价组为14.0%。

综上所述,该研究结果表明,6个月后抗体的持久性对甲型流感菌株比对乙型流感菌株更有利。四价疫苗组在6个月时对额外B株的抗体持久性更优。接种不同B株疫苗的儿童的免疫力并不优于未接种另一B株疫苗的组别。

 

原始出处:

 

Jee Hyun LeeHye Kyung Cho, et al., Evaluation of Waning Immunity at 6 Months after Both Trivalent and Quadrivalent Influenza Vaccination in Korean Children Aged 6-35 Months. J Korean Med Sci. 2019 Dec 2;34(46):e279. doi: 10.3346/jkms.2019.34.e279.

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    2020-09-30 lovetcm

    甲型H1N1、甲型H3N2、乙型山形和乙型维多利亚在6个月后的血清保护率分别为88.7%、97.4%、36.6%和27.6%。现在国内#流感疫苗#接种很难,要排队,尤其是四价疫苗

    1

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