Diabetes Care:妊娠糖尿病女性哺乳时间与2型糖尿病风险

2020-02-12 xing.T MedSci原创

由此可见,哺乳时间较长与GDM女性罹患2型糖尿病的风险降低和葡萄糖代谢生物标志物状态良好有关。其潜在机制及其对糖尿病并发症、发病率和死亡率的影响尚待进一步明确。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员旨在评估妊娠糖尿病(GDM)女性泌乳持续时间与2型糖尿病之间的相关性。

截至2017年,研究人员监测了4372名参加了护士健康研究II且有GDM病史的受试者25年,以观察其2型糖尿病的患病情况。研究人员通过随访问卷获得泌乳史,并计算泌乳持续时间。研究人员通过“糖尿病与女性健康研究”从中位年龄为58岁女性亚组中收集了随访血样。

研究人员在87411人次每年的随访期间记录到了873例2型糖尿病患者。调整年龄、种族、家庭调整后糖尿病史、胎龄、初生年龄、吸烟、饮食质量、体育锻炼和孕前BMI后,泌乳时间越长,2型糖尿病风险就越低(相比于哺乳0月,哺乳6个月风险比为1.05[95%CI为0.83-1.34],6-12个月为0.91[0.72-1.16],12-24个月为0.85 [0.67-1.06],超过24个月为0.73[0.57-0.93];趋势P=0.003)。在随访中,无2型糖尿病女性哺乳时间较长还与较低的HbA1c、空腹血浆胰岛素和C肽浓度相关(所有趋势P均≤0.04)。

由此可见,哺乳时间较长与GDM女性罹患2型糖尿病的风险降低和葡萄糖代谢生物标志物状态良好有关。其潜在机制及其对糖尿病并发症、发病率和死亡率的影响尚待进一步明确。

原始出处:


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    2020-02-12 misszhang

    谢谢MedSci提供最新的资讯

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