心血管

订阅

MedSci主页 / 所有栏目 / 心血管

Diabetes Obes Metab：血浆PCSK9与2型糖尿病患者心血管事件！

2017-12-11 xing.T MedSci原创

PCSK92型糖尿病心血管事件
关注

由此可见，PCSK9与T2DM人群CV事件之间的相关性并不一致。这种关联可能取决于CV风险水平和基础治疗。

前蛋白转化酶枯草溶菌素9（PCSK9）的预测价值，特别是对2型糖尿病（T2DM）仍是未知的。近日，代谢内分泌疾病领域权威杂志Diabetes Obesity & Metabolism上发表了一篇研究文章，研究人员的目的是探讨血浆中PCSK9浓度是否与T2DM患者心血管（CV）事件相关。

研究人员从DIABHYCAR研究（n=3137）和SURDIAGENE研究（n=1468）招募受试者，采用免疫荧光法测定血浆基线PCSK9浓度。在事后预先计划的分析，研究人员评估了PCSK9和下列终点之间的关系：（1）主要心血管事件的复合终点：心血管死亡、非致死性心肌梗死（MI）、卒中和心衰相关入院；（2）所有心血管事件的复合：心肌梗死、脑卒中、心衰相关的入院、冠状动脉和外周血管成形术或搭桥术、心血管死亡；（3）MI；（4）卒中/短暂性脑缺血发作（TIA）以及（5）心血管死亡。

在DIABHYCAR研究中，血浆PCSK9三分位数与MI、所有CV事件以及卒中/TIA的发生相关（趋势P＜0.05）。在调整后的Cox分析中，血浆PCSK9，独立于传统的危险因素，与主要CV事件发生率（PCSK9浓度对数增加一个单位的风险比为1.28（1.06-1.55））、MI的发病率（风险比为1.66（1.05-2.63））和所有的CV事件发生率（风险比为1.22（1.04-1.44））相关，但与CV死亡无关。在采用他汀类药物和胰岛素治疗的高CV风险的SURDIAGENE参与者中，血浆PCSK9与CVD的发生无关。

由此可见，PCSK9与T2DM人群CV事件之间的相关性并不一致。这种关联可能取决于CV风险水平和基础治疗。

原始出处：

Petra El Khoury, et al. Plasma PCSK9 and Cardiovascular Events in Type 2 Diabetes. Diabetes Obesity & Metabolism.2017. http://onlinelibrary.wiley.com/doi/10.1111/dom.13181/full

本文系梅斯医学（MedSci）原创编译整理，转载需授权！

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (121)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=359988, encodeId=ccc13599888f, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Tue Feb 05 13:58:52 CST 2019, time=2019-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359956, encodeId=c7b6359956f2, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Mon Feb 04 23:49:10 CST 2019, time=2019-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359840, encodeId=48a93598400a, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Feb 02 20:36:34 CST 2019, time=2019-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359664, encodeId=672835966437, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Thu Jan 31 13:18:17 CST 2019, time=2019-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359063, encodeId=cfb6359063a6, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Wed Jan 23 21:51:51 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358960, encodeId=4c9a3589602d, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Tue Jan 22 23:28:47 CST 2019, time=2019-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358663, encodeId=06b7358663be, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Jan 19 22:24:34 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357655, encodeId=915b35e65574, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Wed Jan 09 13:51:56 CST 2019, time=2019-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357478, encodeId=336d35e47805, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Mon Jan 07 19:06:51 CST 2019, time=2019-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357269, encodeId=aa8735e269ea, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Jan 05 21:12:33 CST 2019, time=2019-01-05, status=1, ipAttribution=)]
    2019-02-05 zhangqingzui

    好好学习，感谢

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=359988, encodeId=ccc13599888f, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Tue Feb 05 13:58:52 CST 2019, time=2019-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359956, encodeId=c7b6359956f2, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Mon Feb 04 23:49:10 CST 2019, time=2019-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359840, encodeId=48a93598400a, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Feb 02 20:36:34 CST 2019, time=2019-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359664, encodeId=672835966437, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Thu Jan 31 13:18:17 CST 2019, time=2019-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359063, encodeId=cfb6359063a6, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Wed Jan 23 21:51:51 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358960, encodeId=4c9a3589602d, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Tue Jan 22 23:28:47 CST 2019, time=2019-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358663, encodeId=06b7358663be, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Jan 19 22:24:34 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357655, encodeId=915b35e65574, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Wed Jan 09 13:51:56 CST 2019, time=2019-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357478, encodeId=336d35e47805, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Mon Jan 07 19:06:51 CST 2019, time=2019-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357269, encodeId=aa8735e269ea, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Jan 05 21:12:33 CST 2019, time=2019-01-05, status=1, ipAttribution=)]
    2019-02-04 zhangqingzui

    好好学习，感谢

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=359988, encodeId=ccc13599888f, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Tue Feb 05 13:58:52 CST 2019, time=2019-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359956, encodeId=c7b6359956f2, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Mon Feb 04 23:49:10 CST 2019, time=2019-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359840, encodeId=48a93598400a, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Feb 02 20:36:34 CST 2019, time=2019-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359664, encodeId=672835966437, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Thu Jan 31 13:18:17 CST 2019, time=2019-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359063, encodeId=cfb6359063a6, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Wed Jan 23 21:51:51 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358960, encodeId=4c9a3589602d, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Tue Jan 22 23:28:47 CST 2019, time=2019-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358663, encodeId=06b7358663be, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Jan 19 22:24:34 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357655, encodeId=915b35e65574, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Wed Jan 09 13:51:56 CST 2019, time=2019-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357478, encodeId=336d35e47805, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Mon Jan 07 19:06:51 CST 2019, time=2019-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357269, encodeId=aa8735e269ea, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Jan 05 21:12:33 CST 2019, time=2019-01-05, status=1, ipAttribution=)]
    2019-02-02 zhangqingzui

    好好学习，感谢

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=359988, encodeId=ccc13599888f, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Tue Feb 05 13:58:52 CST 2019, time=2019-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359956, encodeId=c7b6359956f2, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Mon Feb 04 23:49:10 CST 2019, time=2019-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359840, encodeId=48a93598400a, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Feb 02 20:36:34 CST 2019, time=2019-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359664, encodeId=672835966437, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Thu Jan 31 13:18:17 CST 2019, time=2019-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359063, encodeId=cfb6359063a6, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Wed Jan 23 21:51:51 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358960, encodeId=4c9a3589602d, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Tue Jan 22 23:28:47 CST 2019, time=2019-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358663, encodeId=06b7358663be, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Jan 19 22:24:34 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357655, encodeId=915b35e65574, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Wed Jan 09 13:51:56 CST 2019, time=2019-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357478, encodeId=336d35e47805, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Mon Jan 07 19:06:51 CST 2019, time=2019-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357269, encodeId=aa8735e269ea, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Jan 05 21:12:33 CST 2019, time=2019-01-05, status=1, ipAttribution=)]
    2019-01-31 zhangqingzui

    好好学习，感谢

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=359988, encodeId=ccc13599888f, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Tue Feb 05 13:58:52 CST 2019, time=2019-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359956, encodeId=c7b6359956f2, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Mon Feb 04 23:49:10 CST 2019, time=2019-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359840, encodeId=48a93598400a, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Feb 02 20:36:34 CST 2019, time=2019-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359664, encodeId=672835966437, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Thu Jan 31 13:18:17 CST 2019, time=2019-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359063, encodeId=cfb6359063a6, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Wed Jan 23 21:51:51 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358960, encodeId=4c9a3589602d, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Tue Jan 22 23:28:47 CST 2019, time=2019-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358663, encodeId=06b7358663be, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Jan 19 22:24:34 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357655, encodeId=915b35e65574, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Wed Jan 09 13:51:56 CST 2019, time=2019-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357478, encodeId=336d35e47805, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Mon Jan 07 19:06:51 CST 2019, time=2019-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357269, encodeId=aa8735e269ea, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Jan 05 21:12:33 CST 2019, time=2019-01-05, status=1, ipAttribution=)]
    2019-01-23 zhangqingzui

    好好学习，感谢

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=359988, encodeId=ccc13599888f, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Tue Feb 05 13:58:52 CST 2019, time=2019-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359956, encodeId=c7b6359956f2, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Mon Feb 04 23:49:10 CST 2019, time=2019-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359840, encodeId=48a93598400a, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Feb 02 20:36:34 CST 2019, time=2019-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359664, encodeId=672835966437, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Thu Jan 31 13:18:17 CST 2019, time=2019-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359063, encodeId=cfb6359063a6, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Wed Jan 23 21:51:51 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358960, encodeId=4c9a3589602d, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Tue Jan 22 23:28:47 CST 2019, time=2019-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358663, encodeId=06b7358663be, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Jan 19 22:24:34 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357655, encodeId=915b35e65574, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Wed Jan 09 13:51:56 CST 2019, time=2019-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357478, encodeId=336d35e47805, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Mon Jan 07 19:06:51 CST 2019, time=2019-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357269, encodeId=aa8735e269ea, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Jan 05 21:12:33 CST 2019, time=2019-01-05, status=1, ipAttribution=)]
    2019-01-22 zhangqingzui

    好好学习，感谢

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=359988, encodeId=ccc13599888f, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Tue Feb 05 13:58:52 CST 2019, time=2019-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359956, encodeId=c7b6359956f2, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Mon Feb 04 23:49:10 CST 2019, time=2019-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359840, encodeId=48a93598400a, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Feb 02 20:36:34 CST 2019, time=2019-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359664, encodeId=672835966437, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Thu Jan 31 13:18:17 CST 2019, time=2019-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359063, encodeId=cfb6359063a6, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Wed Jan 23 21:51:51 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358960, encodeId=4c9a3589602d, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Tue Jan 22 23:28:47 CST 2019, time=2019-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358663, encodeId=06b7358663be, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Jan 19 22:24:34 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357655, encodeId=915b35e65574, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Wed Jan 09 13:51:56 CST 2019, time=2019-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357478, encodeId=336d35e47805, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Mon Jan 07 19:06:51 CST 2019, time=2019-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357269, encodeId=aa8735e269ea, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Jan 05 21:12:33 CST 2019, time=2019-01-05, status=1, ipAttribution=)]
    2019-01-19 zhangqingzui

    好好学习，感谢

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=359988, encodeId=ccc13599888f, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Tue Feb 05 13:58:52 CST 2019, time=2019-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359956, encodeId=c7b6359956f2, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Mon Feb 04 23:49:10 CST 2019, time=2019-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359840, encodeId=48a93598400a, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Feb 02 20:36:34 CST 2019, time=2019-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359664, encodeId=672835966437, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Thu Jan 31 13:18:17 CST 2019, time=2019-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359063, encodeId=cfb6359063a6, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Wed Jan 23 21:51:51 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358960, encodeId=4c9a3589602d, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Tue Jan 22 23:28:47 CST 2019, time=2019-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358663, encodeId=06b7358663be, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Jan 19 22:24:34 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357655, encodeId=915b35e65574, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Wed Jan 09 13:51:56 CST 2019, time=2019-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357478, encodeId=336d35e47805, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Mon Jan 07 19:06:51 CST 2019, time=2019-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357269, encodeId=aa8735e269ea, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Jan 05 21:12:33 CST 2019, time=2019-01-05, status=1, ipAttribution=)]
    2019-01-09 zhangqingzui

    好好学习，感谢

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=359988, encodeId=ccc13599888f, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Tue Feb 05 13:58:52 CST 2019, time=2019-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359956, encodeId=c7b6359956f2, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Mon Feb 04 23:49:10 CST 2019, time=2019-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359840, encodeId=48a93598400a, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Feb 02 20:36:34 CST 2019, time=2019-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359664, encodeId=672835966437, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Thu Jan 31 13:18:17 CST 2019, time=2019-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359063, encodeId=cfb6359063a6, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Wed Jan 23 21:51:51 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358960, encodeId=4c9a3589602d, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Tue Jan 22 23:28:47 CST 2019, time=2019-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358663, encodeId=06b7358663be, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Jan 19 22:24:34 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357655, encodeId=915b35e65574, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Wed Jan 09 13:51:56 CST 2019, time=2019-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357478, encodeId=336d35e47805, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Mon Jan 07 19:06:51 CST 2019, time=2019-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357269, encodeId=aa8735e269ea, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Jan 05 21:12:33 CST 2019, time=2019-01-05, status=1, ipAttribution=)]
    2019-01-07 zhangqingzui

    好好学习，感谢

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=359988, encodeId=ccc13599888f, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Tue Feb 05 13:58:52 CST 2019, time=2019-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359956, encodeId=c7b6359956f2, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Mon Feb 04 23:49:10 CST 2019, time=2019-02-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359840, encodeId=48a93598400a, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Feb 02 20:36:34 CST 2019, time=2019-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359664, encodeId=672835966437, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Thu Jan 31 13:18:17 CST 2019, time=2019-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359063, encodeId=cfb6359063a6, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Wed Jan 23 21:51:51 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358960, encodeId=4c9a3589602d, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Tue Jan 22 23:28:47 CST 2019, time=2019-01-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358663, encodeId=06b7358663be, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Jan 19 22:24:34 CST 2019, time=2019-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357655, encodeId=915b35e65574, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Wed Jan 09 13:51:56 CST 2019, time=2019-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357478, encodeId=336d35e47805, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Mon Jan 07 19:06:51 CST 2019, time=2019-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=357269, encodeId=aa8735e269ea, content=好好学习，感谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2cQVB0w6wKXcuEC4Enl0NTBvgHc6yoUM80A3TDia90Fo2MPicibnfm59eh7A0WoicrZXI2hde9ctxKPrlXhzNdL6oZ/0, createdBy=27371624227, createdName=zhangqingzui, createdTime=Sat Jan 05 21:12:33 CST 2019, time=2019-01-05, status=1, ipAttribution=)]
    2019-01-05 zhangqingzui

    好好学习，感谢

    0

以上为热门评论，梅斯医学App还有更多内容

相关资讯

NEJM：Evolocumab 治疗对于认知功能影响研究

Evolocumab联合他汀类药物不会对患者的认知功能造成影响

JCEM：PCSK9的功能丧失变异能降低空腹和餐后脂肪及脂蛋白

低密度脂蛋白胆固醇（LDL-C）主要通过肝细胞表面的低密度脂蛋白受体（LDLR）清除。前蛋白转化酶枯草溶菌素9（PCSK9）是由肝脏合成的蛋白酶，释放入血后与LDLR结合，引导后者进入肝细胞后至溶酶体降解，从而减少肝细胞表面的LDLR数量，使血浆LDL-C水平升高。PCSK9基因的变异与PCSK9的功能丧失（LOF）相关，会导致肝LDLR的表达增加，LDL-C的浓度降低，以及预防心血管疾病（CVD

EUR HEART J ：PCSK9基因变异对冠心病和缺血性脑卒中的影响

PCSK9基因变异对低密度脂蛋白胆固醇(LDL-C)和冠心病(CHD)有很大的影响，促进了PCSK9抑制剂治疗的发展。然而，有证据表明PCSK9变异与缺血脑卒中（IS）有关。近日，在医学权威杂志EUR HEART J 上面发表了一篇研究文章，该文章旨在探讨PCSK9基因变异对冠心病和缺血性脑卒中的影响。

Metabolism：杂合子家族性高胆固醇血症Lp（a）与PCSK9之间的相关性分析！

由此可见，HeFH患者血浆Lp（a）水平与PCSK9相关，提示对FH患者中PCSK9与LP（a）之间的相互作用需要进一步探索。

JACC：PCSK9可作为心衰患者预后的预测因子

前蛋白转化酶枯草溶菌素9（PCSK9）可以靶向结合低密度脂蛋白受体（LDLR），防止其再循环利用。因此，PCSK9可作为动脉粥样硬化的预测因子和药物的靶点。本研究的目的是评估PCSK9-LDLR对心衰患者是否有降低动脉粥样硬化风险的作用。本研究纳入的是BIOSTAT-CHF临床试验中的心衰患者，主要终点事件是全因死亡率、心衰的复合死亡率和心衰的住院率。最终共纳入了2174名心衰患者（平均年龄为68

JAHA：循环中PCSK9水平与动脉硬化相关吗？

在布里西盖拉心脏研究中，循环PCSK9水平是动脉硬化显著相关，并且独立于性别以及女性的绝经状态。