JAMA:妊娠期糖尿病新生儿围产期并发症的预防——格列本脲VS胰岛素

2018-05-02 zhangfan MedSci原创

研究认为,格列本脲和胰岛素对妊娠期糖尿病新生儿围产期并发症的预防效果差异不显著,胰岛素仍是妊娠期糖尿病的首选治疗药物

近日研究人员比较了口服格列本脲或皮下注射胰岛素对妊娠期糖尿病新生儿围产期并发症的预防效果差异。

INDAO研究在法国13个3级中心开展,包含914名孕24-34周的妊娠糖尿病孕妇。参与者随机接受格列本脲(n=460)或胰岛素治疗(n=454)。格列本脲组起始剂量为2.5mg,逐步增加至最大剂量为20mg/天。胰岛素组起始剂量为4-20IU,每天1-4次,根据自测血糖浓度增加注射剂量。研究的终点为巨大儿、新生儿低血糖和高胆红素血症的复合终点。非劣性边界设定为7%。

98%的参与者完成研究,参与者平均年龄32.8岁。格列本脲和胰岛素组分别有367名和442名参与者及其后代参与结果分析,其中27.6%的格列本脲组和23.4%的胰岛素组参与者出现终点事件,组间差异为4.2%,二者治疗手段差异不显著。

研究认为,格列本脲和胰岛素对妊娠期糖尿病新生儿围产期并发症的预防效果差异不显著,胰岛素仍是妊娠期糖尿病的首选治疗药物。

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    2018-12-22 丁鹏鹏
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    2019-04-02 baoya
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    2018-05-02 清风拂面

    谢谢分享学习

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    2018-05-02 医者仁心5538

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