JAHA:腰肌质量指数在非ST段抬高型心肌梗死患者中的预后价值

2020-09-27 MedSci原创 MedSci原创

由PMI定义的肌肉消瘦,是预测非ST段抬高型心肌梗死患者未来心血管预后简单而有用的客观指标。

肌肉消瘦是血管疾病患者长期预后的重要预测指标,但尚未确定肌肉消瘦对非ST段抬高型心肌梗死患者的预后价值。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,这项研究旨在探究由腰肌质量指数(PMI)定义的肌肉消瘦对非ST段抬高型心肌梗死患者的预后价值。

2015年至2018年间,研究人员共前瞻性地招募了132例非ST段抬高型心肌梗死患者。该研究的主要终点为心血管事件发生率,包括心血管死亡、非致命性心肌梗塞或非致命性卒中。通过计算机断层扫描获得L3椎体层面的腰肌横截面积,并计算PMI。

中位随访期为2.4年(四分位间距为1.1-4.0年)。在研究期间发生了45次心血管事件(34%)。通过受试者工作曲线分析评估,预测心血管事件的最佳PMI临界值为772 mm2/m2。PMI降低(PMI<772 mm2/m2)的患者的心血管事件明显高于PMI正常(PMI≥772mm2/m2)的患者(48% vs. 21%;对数检验P<0.001)。多元Cox比例风险模型显示,PMI降低是心血管事件的预测因子(风险比为3.30;95%CI为1.70–6.40;P<0.001)。

由此可见,由PMI定义的肌肉消瘦,是预测非ST段抬高型心肌梗死患者未来心血管预后简单而有用的客观指标。

原始出处:

Hiroshi Matsumoto.et al.Prognostic Value of Psoas Muscle Mass Index in Patients With Non‒ST‐Segment‒Elevation Myocardial Infarction: A Prospective Observational Study.J AM HEART ASSOC.2020.https://www.ahajournals.org/doi/10.1161/JAHA.120.017315

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    2021-08-22 lxg951
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  5. 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    2020-10-25 ms2000000888041701

    学习了

    0

  6. 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    2020-09-30 咻凡

    考虑到非标准化的疾病标准,应考虑进一步设计良好的前瞻性试验以证实这些结果。

    0

  7. 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    2020-09-29 zhaohui6731
  8. 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    2020-09-29 gdsun
  10. 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    2020-09-29 hyf035

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