JAHA:腹主动脉钙化的预后价值

2021-01-14 MedSci原创 MedSci原创

高风险人群,例如伴有AAC的老年人和慢性肾脏疾病人群,未来发生心血管事件的风险大大增加,患者预后也较差。分析AAC的相关信息可以帮助临床医生更好地了解和管理患者的心血管风险。

通过无创成像方式观察到的腹主动脉钙化(AAC)的预后意义尚未明确。近日,血管疾病领域权威杂志JAHA上针对这一问题发表了一篇研究文章。

研究人员检索了MEDLINE、Embase等电子数据库,检索时间截止至2018年3月。多位作者确定了报告了AAC与心血管事件或全因死亡率之间关系的前瞻性研究。两名作者独立评估了研究是否符合纳入标准以及偏倚风险,并提取了研究数据。研究人员使用随机效应模型估算汇总的风险比(RR),将AAC程度较高组(任何或更多晚期AAC)与AAC程度较低组进行比较。

研究人员确定了52项研究(46个队列,36092名参与者);只有对慢性肾脏病患者(57%)和一般老年人(中位年龄为68岁;范围为60-80岁)(26%)的研究具有足够的数据进行荟萃分析。患有任何或更晚期的AAC患者发生心血管事件(RR为1.83;95%CI为1.40-2.39)、致命性心血管事件(RR为1.85; 95%CI为1.44-2.39)和全因死亡(RR为1.98;95%CI为1.55-2.53)的风险更高。患有任何或更晚期AAC的慢性肾脏疾病患者发生心血管事件(RR为3.47; 95%CI为2.21-5.45)、致命性心血管事件(RR为3.68; 95%CI为2.32-5.84)和全因死亡(RR为2.40;95%CI为1.95-2.97)的风险较高。

由此可见,高风险人群,例如伴有AAC的老年人和慢性肾脏疾病人群,未来发生心血管事件的风险大大增加,患者预后也较差。分析AAC的相关信息可以帮助临床医生更好地了解和管理患者的心血管风险。

原始出处:

Kevin Leow.et al.Prognostic Value of Abdominal Aortic Calcification: A Systematic Review and Meta‐Analysis of Observational Studies.J AM HEART ASSOC.2021.https://doi.org/10.1161/JAHA.120.017205

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    学习

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    2021-01-16 zhaohui6731
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